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dc.contributor.authorHagve, Martin Iversen
dc.contributor.authorGjessing, Petter Fosse
dc.contributor.authorHole, Mikal Jacob
dc.contributor.authorJansen, Kirsten M
dc.contributor.authorFuskevåg, Ole Martin
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorLarsen, Terje S
dc.contributor.authorIrtun, Øivind
dc.date.accessioned2020-02-14T10:01:26Z
dc.date.available2020-02-14T10:01:26Z
dc.date.embargoEndDate2020-10-07
dc.date.issued2019-10-07
dc.description.abstractInsulin resistance is an independent negative predictor of outcome after elective surgery and increases mortality among surgical patients in intensive care. The incretin hormone glucagon-like peptide-1 (GLP-1) potentiates glucose-induced insulin release from the pancreas but may also increase insulin sensitivity in skeletal muscle and directly suppress hepatic glucose release. Here, we investigated whether a perioperative infusion of GLP-1 could counteract the development of insulin resistance after surgery. Pigs were randomly assigned to three groups; surgery/control, surgery/GLP-1, and sham/GLP-1. Both surgery groups underwent major abdominal surgery. Whole-body glucose disposal (WGD) and endogenous glucose release (EGR) were assessed preoperatively and postoperatively using D-[6,6-<sup>2</sup>H<sub>2</sub>]-glucose infusion in combination with hyperinsulinemic euglycemic step-clamping. In the surgery/control group, peripheral insulin sensitivity (<i>i.e.</i>, WGD) was reduced by 44% relative to preoperative conditions, whereas the corresponding decline was only 9% for surgery/GLP-1 (<i>P</i> < 0.05). Hepatic insulin sensitivity (<i>i.e.</i>, EGR) remained unchanged in the surgery/control group but was enhanced after GLP-1 infusion in both surgery and sham animals (40% and 104%, respectively, both <i>P</i> < 0.05). Intraoperative plasma glucose increased in surgery/control (∼20%) but remained unchanged in both groups receiving GLP-1 (<i>P</i> < 0.05). GLP-1 diminished an increase in postoperative glucagon levels but did not affect skeletal muscle glycogen or insulin signaling proteins after surgery. We show that GLP-1 improves intraoperative glycemic control, diminishes peripheral insulin resistance after surgery, and suppresses EGR. This study supports the use of GLP-1 to prevent development of postoperative insulin resistance.en_US
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in Endocrinology following peer review. The version of record Hagve, M., Gjessing, P. F., Hole, M. J., Jansen, K. M., Fuskevåg, O. M., Mollnes, T. E., ... Irtun, Ø. (2019) Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs. <i>Endocrinology, 160</i>(12), 2892–2902. is available online at: <a href=https://doi.org/10.1210/en.2019-00374>https://doi.org/10.1210/en.2019-00374</a>en_US
dc.identifier.citationHagve M, Gjessing PF, Hole MJ, Jansen K, Fuskevåg O, Mollnes TE, Larsen t, Irtun Ø. Perioperative infusion of glucagon-like peptide-1 prevents insulin resistance after surgical trauma in female pigs. Endocrinology. 2019;160(12):2892-2902en_US
dc.identifier.cristinIDFRIDAID 1756929
dc.identifier.doi10.1210/en.2019-00374
dc.identifier.issn0013-7227
dc.identifier.issn1945-7170
dc.identifier.urihttps://hdl.handle.net/10037/17395
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalEndocrinology
dc.rights.accessRightsembargoedAccessen_US
dc.rights.holderCopyright © 2019, Oxford University Pressen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titlePerioperative infusion of glucagon-like peptide-1 prevents insulin resistance after surgical trauma in female pigsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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