ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Universitetsbiblioteket
  • Artikler, rapporter og annet (UB)
  • View Item
  •   Home
  • Universitetsbiblioteket
  • Artikler, rapporter og annet (UB)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Reduced grey matter volume in frontal and temporal areas in depression: Contributions from voxel-based morphometry study

Permanent link
https://hdl.handle.net/10037/17453
DOI
https://doi.org/10.1017/neu.2019.20
Thumbnail
View/Open
article.pdf (628.9Kb)
Submitted manuscript version (PDF)
Date
2019-06-25
Type
Journal article
Tidsskriftartikkel

Author
Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Sirakov, Nickolay; Maes, Michael; Specht, Karsten
Abstract
Objective: The aim of the current study was to examine whether and to what extent mood disorders, comprising major depression and bipolar disorder, are accompanied by structural changes in the brain as measured using voxel-based morphometry (VBM).

Methods: We performed a VBM study using a 3Т MRI system (GE Discovery 750w) in patients with mood disorders (n=50), namely, 39 with major depression and 11 with bipolar disorder compared to 42 age-, sex- and education-matched healthy controls.

Results: Our results show that depression was associated with significant decreases in grey matter (GM) volume of the regions located within the medial frontal and anterior cingulate cortex on the left side and middle frontal gyrus, medial orbital gyrus, inferior frontal gyrus (triangular and orbital parts) and middle temporal gyrus (extending to the superior temporal gyrus) on the right side. When the patient group was separated into bipolar disorder and major depression, the reductions remained significant only for patients with major depressive disorder.

Conclusions: Using VBM the present study was able to replicate decreases in GM volume restricted to frontal and temporal regions in patients with mood disorders, mainly major depression, compared with healthy controls.

Publisher
Cambridge University Press (CUP)
Citation
Kandilarova S, Stoyanov D, Sirakov, Maes M, Specht K. Reduced grey matter volume in frontal and temporal areas in depression: Contributions from voxel-based morphometry study. Acta Neuropsychiatrica. 2019:1-6
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (UB) [3245]
Copyright 2019 The Author(s)

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)