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dc.contributor.authorAndersen, Thomas
dc.contributor.authorUeland, Thor
dc.contributor.authorGhukasyan Lakic, Tatevik
dc.contributor.authorÅkerblom, Axel
dc.contributor.authorBertilsson, Maria
dc.contributor.authorAukrust, Pål
dc.contributor.authorMichelsen, Annika E
dc.contributor.authorJames, Stefan K.
dc.contributor.authorBecker, Richard C.
dc.contributor.authorStorey, Robert F.
dc.contributor.authorWallentin, Lars
dc.contributor.authorSiegbahn, Agneta
dc.contributor.authorKontny, Frederic
dc.date.accessioned2020-02-27T12:50:16Z
dc.date.available2020-02-27T12:50:16Z
dc.date.embargoEndDate2020-09-26
dc.date.issued2019-09-26
dc.description.abstract<i>Objective:</i> - The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome.<p> <p><i>Approach and Results:</i> - Serial measurements of CXCL16 were performed in a subgroup of 5142 patients randomized in the PLATO trial (Platelet Inhibition and Patient Outcome). Associations between CXCL16 and a composite of cardiovascular death, spontaneous myocardial infarction or stroke, and the individual components were assessed by multivariable Cox regression analyses. The hazard ratio per 50% increase in admission levels of CXCL16 analyzed as continuous variable was 1.64 (95% CI, 1.44–1.88), <i>P</i><0.0001. This association remained statistically significant after adjustment for randomized treatment, clinical variables, CRP (C-reactive protein), leukocytes, cystatin C, NT-proBNP (N-terminal pro-brain natriuretic peptide), troponin T, GDF-15 (growth differentiation factor 15), and other biomarkers; hazard ratio 1.23 (1.05–1.45), <i>P</i>=0.0126. The admission level of CXCL16 was independently associated with cardiovascular death (1.50 [1.17–1.92], P=0.0014) but not with ischemic events alone, in fully adjusted analyses. No statistically independent association was found between CXCL16 measured at 1 month, or change in CXCL16 from admission to 1 month, and clinical outcomes.<p> <p><i>Conclusions:</i> - In patients with acute coronary syndrome, admission level of CXCL16 is independently related to adverse clinical outcomes, mainly driven by an association to cardiovascular death. Thus, CXCL16 measurement may enhance risk stratification in patients with this condition.en_US
dc.identifier.citationAndersen T, Ueland T, Ghukasyan Lakic, Åkerblom A, Bertilsson M, Aukrust P, Michelsen A, James SK, Becker RC, Storey RF, Wallentin L, Siegbahn A, Kontny F. C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology. 2019;39(11):2402-2410en_US
dc.identifier.cristinIDFRIDAID 1747540
dc.identifier.doi10.1161/ATVBAHA.119.312633
dc.identifier.issn1079-5642
dc.identifier.issn1524-4636
dc.identifier.urihttps://hdl.handle.net/10037/17539
dc.language.isoengen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.journalArteriosclerosis, Thrombosis and Vascular Biology
dc.rights.accessRightsembargoedAccessen_US
dc.rights.holder© 2019 American Heart Association, Inc.en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleC-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromesen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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