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A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes

Permanent lenke
https://hdl.handle.net/10037/17621
DOI
https://doi.org/10.1016/j.celrep.2019.09.088
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article.pdf (8.316Mb)
Publisert versjon (PDF)
Dato
2019-11-05
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Dusart, Philip James; Hallström, Björn M.; Renne, Thomas; Odeberg, Jacob Olof; Uhlén, Mathias; Butler, Lynn
Sammendrag
Changes in the endothelium of the cerebral vasculature can contribute to inflammatory, thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and their modification in disease is increasingly recognized. Here, we develop a bioinformatics-based approach to identify normal brain cell-enriched genes, using bulk RNA sequencing (RNA-seq) data from 238 normal human cortex samples from 2 independent cohorts. We compare endothelial cell-enriched gene profiles with astrocyte, oligodendrocyte, neuron, and microglial cell profiles. Endothelial changes in malignant disease are explored using RNA-seq data from 516 lower-grade gliomas and 401 glioblastomas. Lower-grade gliomas appear to be an “endothelial intermediate” between normal brain and glioblastoma. We apply our method for the prediction of glioblastoma-specific endothelial biomarkers, providing potential diagnostic or therapeutic targets. In summary, we provide a roadmap of endothelial cell identity in normal and malignant brain, using a method developed to resolve bulk RNA-seq into constituent cell-type-enriched profiles.
Forlag
Elsevier
Sitering
Dusart PJ, Hallström BM, Renne, Odeberg JO, Uhlén M, Butler LB. A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes. Cell reports. 2019;29(6):1690-1706.e4
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2019 The Author(s)

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