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dc.contributor.authorKuttner, Samuel
dc.contributor.authorLassen, Martin Lyngby
dc.contributor.authorØen, Silje Kjærnes
dc.contributor.authorSundset, Rune
dc.contributor.authorBeyer, Thomas
dc.contributor.authorEikenes, Live
dc.date.accessioned2020-03-16T07:55:28Z
dc.date.available2020-03-16T07:55:28Z
dc.date.issued2019-04-13
dc.description.abstract<i>Background</i> - Positron emission tomography (PET)/magnetic resonance (MR) imaging may become increasingly important for assessing tumor therapy response. A prerequisite for quantitative PET/MR imaging is reliable and repeatable MR-based attenuation correction (AC).<p> <p><i>Purpose</i> - To investigate the frequency and test–retest reproducibility of artifacts in MR-AC maps in a lung cancer patient cohort and to study the impact of artifact corrections on PET-based tumor quantification.<p> <p><i>Material and Methods</i> - Twenty-five lung cancer patients underwent single-day, test–retest, <sup>18</sup>F-fluorodeoxyglucose (FDG) PET/MR imaging. The acquired MR-AC maps were inspected for truncation, susceptibility, and tissue inversion artifacts. An anatomy-based bone template and a PET-based estimation of truncated arms were employed, while susceptibility artifacts were corrected manually. We report the frequencies of artifacts and the relative difference (RD) on standardized uptake value (SUV) based quantification in PET images reconstructed with the corrected AC maps.<p> <p><i>Results</i> - Truncation artifacts were found in all 50 acquisitions (100%), while susceptibility and tissue inversion artifacts were observed in six (12%) and 26 (52%) of the scans, respectively. The RD in lung tumor SUV was < 5% from bone and truncation corrections, while up to 20% RD was introduced after susceptibility artifact correction, with large inconsistencies between test–retest scans.<p> <p><i>Conclusion</i> - The absence of bone and truncation artifacts have limited effect on the PET quantification of lung lesions. In contrast, susceptibility artifacts caused significant and inconsistent underestimations of the lung tumor SUVs, between test–retest scans. This may have clinical implications for patients undergoing serial imaging for tumor therapy response assessment.en_US
dc.identifier.citationKuttner S, Lassen ML, Øen SK, Sundset R, Beyer T, Eikenes L. Quantitative PET/MR imaging of lung cancer in the presence of artifacts in the MR-based attenuation correction maps. Acta Radiologica. 2019:1-10en_US
dc.identifier.cristinIDFRIDAID 1709224
dc.identifier.doi10.1177/0284185119848118
dc.identifier.issn0284-1851
dc.identifier.issn1600-0455
dc.identifier.urihttps://hdl.handle.net/10037/17739
dc.language.isoengen_US
dc.publisherSAGE Publicationsen_US
dc.relation.ispartofKuttner, S. (2021). Advancing Quantitative PET Imaging with Machine Learning. (Doctoral thesis). <a href=https://hdl.handle.net/10037/21186>https://hdl.handle.net/10037/21186</a>.
dc.relation.journalActa Radiologica
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© The Foundation Acta Radiologica 2019en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleQuantitative PET/MR imaging of lung cancer in the presence of artifacts in the MR-based attenuation correction mapsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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