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Second re-irradiation: A delicate balance between safety and efficacy

Permanent lenke
https://hdl.handle.net/10037/17904
DOI
https://doi.org/10.1016/j.ejmp.2019.01.004
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article.pdf (267.0Kb)
Akseptert manusversjon (PDF)
Dato
2019-01-08
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Nieder, Carsten
Sammendrag
Except for straightforward palliative indications such as painful bone metastases, re-irradiation is often characterized by a narrow therapeutic window and the potential for decreased efficacy and increased toxicity, especially if the cumulative total dose from both courses is high. Second re-irradiations tend to pose even bigger challenges and are thus offered in a restrictive manner to highly selected patients on a case-by-case basis. Normal tissue dose constraints are still an area of active investigation. Nevertheless, examples of potentially useful indications have been published. The present review briefly summarizes areas of uncertainty and opportunities for future research. If evidence-based concepts with acceptable side effect profiles can be developed, an increasing number of patients may benefit from additional radiotherapy to previously exposed target volumes.
Forlag
Elsevier
Sitering
Nieder, C. (2019) Second re-irradiation: A delicate balance between safety and efficacy. Physica medica (Testo stampato), 58, , 155-158
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd.

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