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dc.contributor.advisorTernullo, Selenia
dc.contributor.advisorSkalko-Basnet, Natasa
dc.contributor.authorGagnat, Eivind
dc.date.accessioned2020-05-15T15:18:16Z
dc.date.available2020-05-15T15:18:16Z
dc.date.issued2018-05-15
dc.description.abstractChronic wounds are today representing a major challenge in global healthcare due the difficulty to treat as well as the costs for the society. Therefore, improving chronic wound therapy is an urgent need. Curcumin, a polyphenol compound, has shown to have potential in wound therapy due to its anti-inflammatory, anti-infectious and anti-oxidant properties. However, the poor water solubility, low bioavailability and rapid degradation represent major challenges in optimizing formulation of curcumin for delivery. The aim of this study was to develop deformable liposomes to improve dermal delivery of curcumin. The liposomes were prepared by thin film hydration method and extruded through polycarbonate membranes to obtain the desired vesicle size. The deformable liposomes were characterized for the size, polydispersity, surface charge and entrapment efficiency. In vitro and ex vivo curcumin release from the deformable liposomes were examined using Franz diffusion cells with cellophane and full-thickness human skin as membranes, respectively. Anti-inflammatory activity, anti-bacterial activity and cell proliferation studies of the different deformable liposomes were assessed to confirm the potential in treatment of chronic wounds.en_US
dc.identifier.urihttps://hdl.handle.net/10037/18307
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2018 The Author(s)
dc.subject.courseIDFAR-3911
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Biopharmacy: 736en_US
dc.titleImproved chronic wound therapy: surface charged deformable liposomes for dermal delivery of curcuminen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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