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Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA)

Permanent lenke
https://hdl.handle.net/10037/18529
DOI
https://doi.org/10.1186/s13014-020-1484-9
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article.pdf (640.3Kb)
Publisert versjon (PDF)
Dato
2020-02-13
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L.
Sammendrag
Purpose - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).

Patients and Methods - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain metastases, performance status and other variables was collected. The GI-GPA score was calculated as described by Sperduto et al.

Results - Median survival was 4 months. The corresponding figures for the 4 different prognostic strata were 2.3, 4.4, 9.4 and 12.7 months, respectively (p = 0.0001). Patients whose management included surgical resection had longer median survival than those who were treated with other approaches (median 11.9 versus 3.0 months, p = 0.002). Comparable results were seen for additional systemic therapy (median 8.5 versus 3.5 months, p = 0.01).

Conclusion - These results confirm the validity of the GI-GPA in an independent dataset from a different geographical region, despite the fact that overall survival was shorter in all prognostic strata, compared to Sperduto et al. Potential explanations include differences in molecular tumor characteristics and treatment selection, both brain metastases-directed and extracranially. Long-term survival beyond 5 years is possible in a small minority of patients.

Forlag
BMC
Sitering
Nieder C, Hintz M, Popp I, Bilger A, Grosu AL. Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA). Radiation Oncology. 2020;15:35(1):1-6
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2020 The Author(s)

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