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Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: Potential immune-regulatory role during malaria

Permanent link
https://hdl.handle.net/10037/18626
DOI
https://doi.org/10.1186/s12879-020-4783-8
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Date
2020-01-21
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Otterdal, Kari; Berg, Aase; Michelsen, Annika; Patel, Sam; Gregersen, Ida; Sagen, Ellen Lund; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Langeland, Nina; Aukrust, Pål
Abstract
Background - The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic cytokine exerting both inflammatory and anti-inflammatory effects, but data on IL-27 in malaria patients are scarce.

Methods - Clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) HIV-1 co-infection, from HIV-infected patients with similar symptoms without malaria (n = 58) and from healthy controls (n = 52). In vitro studies were performed in endothelial cells and PBMC using hemozoin crystals. Samples were analyzed using enzyme immunoassays and quantitative PCR.

Results - (i) IL-27 was markedly up-regulated in malaria patients compared with controls and HIV-infected patients without malaria, showing no relation to HIV co-infection. (ii) IL-27 was correlated with P. falciparum parasitemia and von Willebrand factor as a marker of endothelial activation, but not with disease severity. (iii) In vitro, IL-27 modulated the hemozoin-mediated cytokine response in endothelial cells and PBMC with enhancing effects on IL-6 and attenuating effects on IL-8.

Conclusion - Our findings show that IL-27 is regulated during falciparum malaria, mediating both inflammatory and anti-inflammatory effects, potentially playing an immune-regulatory role during falciparum malaria.

Publisher
BMC
Citation
Otterdal K, Berg Ã, Michelsen A, Patel S, Gregersen I, Sagen EL, Halvorsen BE, Yndestad A, Ueland T, Langeland N, Aukrust P. Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: Potential immune-regulatory role during malaria. BMC Infectious Diseases. 2020;20:65:1-11
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