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dc.contributor.authorNordheim, Espen
dc.contributor.authorDahle, Dag Olav
dc.contributor.authorStrøm Halden, Thea Anine
dc.contributor.authorBirkeland, Kåre I.
dc.contributor.authorÅsberg, Anders
dc.contributor.authorHartmann, Anders
dc.contributor.authorHorneland, Rune
dc.contributor.authorJenssen, Trond Geir
dc.date.accessioned2020-07-01T12:36:20Z
dc.date.available2020-07-01T12:36:20Z
dc.date.embargoEndDate2021-02-06
dc.date.issued2020-02-06
dc.description.abstract<i>Background</i> - Patients with diabetes mellitus treated with successful pancreas transplantation (PTX) normalize hyperglycemia, but are exposed to immunosuppressive drugs that may impair endothelial function. This study aimed to evaluate endothelial function in single PTX recipients.<p><p> <i>Methods</i> - Flow‐mediated dilatation (FMD) in the brachial artery was measured by ultrasound 8 weeks after transplantation in single PTX (n = 27) and compared with healthy controls (n = 58), simultaneous pancreas and kidney recipients (n = 9), and kidney transplant recipients with (n = 41) and without (n = 95) diabetes mellitus. Adjustments for age, gender, blood pressure, and body mass index were included in a linear regression model. Changes in FMD from before to 1 year after transplantation were assessed in a subgroup of PTX recipients (n = 9).<p><p> <i>Results</i> - Flow‐mediated dilatation% in PTX recipients was not inferior to healthy controls (8.7 ± 3.6 vs 7.7 ± 3.3, <i>P</i> = .06) and simultaneous pancreas and kidney recipients (6.7 ± 4.5, <i>P</i> = .24) in an adjusted model, and superior to kidney recipients with and without diabetes (3.0 ± 3.0 and 4.8 ± 3.3, respectively, both <i>P</i> < .005). FMD% improved significantly from eight weeks to one year after PTX, mean 7.9 ± 4.2% vs 11.8 ± 4.8% (N = 9; <i>P</i> = .03).<p><p> <i>Conclusion</i> - Flow‐mediated dilatation is well preserved in patients undergoing pancreas transplantation and is not impaired when immunosuppressive drugs are introduced.en_US
dc.descriptionThis is the peer reviewed version of the following article: Nordheim, E., Dahle, D. O., Halden, T., Birkeland, K. I., Åsberg, A., Hartmann, A., ... Jenssen, T. G. (2020). Endothelial function after pancreas transplantation - A single‐center observational study. <i>Clinical Transplantation, 34</i>(3), ?., which has been published in final form at <a href=https://doi.org/10.1111/ctr.13815>https://doi.org/10.1111/ctr.13815</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationNordheim, Dahle, Strøm Halden, Birkeland, Åsberg, Hartmann, Horneland, Jenssen. Endothelial function after pancreas transplantation - A single-center observational study. Clinical Transplantation. 2020;34:e13815(3):1-7en_US
dc.identifier.cristinIDFRIDAID 1802793
dc.identifier.doi10.1111/ctr.13815
dc.identifier.issn0902-0063
dc.identifier.issn1399-0012
dc.identifier.urihttps://hdl.handle.net/10037/18741
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalClinical Transplantation
dc.rights.accessRightsembargoedAccessen_US
dc.rights.holder© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltden_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleEndothelial function after pancreas transplantation - A single-center observational studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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