Blar i forfatter Mastergradsoppgaver i farmasi "Evjen, Tove Julie"
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Development of improved bendamustin-liposomes
Evjen, Tove Julie (Master thesis; Mastergradsoppgave, 2007-05)Bendamustin is an alkylating anticancer agent which is currently in routine use for the treatment of different types of cancer. The drug is very unstable in serum due to hydrolysis; the half life of the first part of the serum elimination curve is about 6-10 minutes. The rapid degradation of the drug in serum impairs its cytostatic action within a short period of time, and frequent application of ...