• In silico screening for GAT-3 inhibitors 

      Gebregazabhier, Reem Alem (Master thesis; Mastergradsoppgave, 2017-05-15)
      ϒ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the central nervous system (CNS). GABA exert is function by binding to three different receptor subtypes, the GABAA, GABAB and GABAC receptor. The GABA level in different brain regions are regulated by four GABA transporters (GATs); GAT-1, GAT-2, GAT-3 and BGT-1. GAT-3 is located in glial cells that is controlling GABA function ...