Viser treff 61-80 av 298

    • Evaluation and Late-Stage Fluorination of Small Molecule GnRH-R Antagonists 

      Rustad, Eirik André Lindeløff (Mastergradsoppgave; Master thesis, 2019-05-15)
      Alzheimer’s disease is the most common type of dementia; causing problems with memory, thinking and behaviour. The seemingly protective effect of hormone replacement therapy against Alzheimer’s disease sparked an interest in the role of the sex hormone system. Sex steroid production is dependent on gonadotropins released in the pituitary. The gonadotropin level is controlled by gonadotropin releasing ...
    • Liposomes-in-hydrogel delivery system containing resveratrol for the local treatment of vaginal infections 

      Tostrup, Mia Jonine (Mastergradsoppgave; Master thesis, 2018-05-15)
      Administering drug formulations to the vagina is a challenge since the vagina possesses “self-cleaning” features which allow trapping and rapid removing of foreign particles. Therefore, the residence time of drugs is often too short to offer a sufficient clinical effect. The aim of this project was to develop and optimize a liposomes-in-hydrogel system containing resveratrol for the local treatment ...
    • How will anonymization of simulated clinical data affect the data utility of pharmacoepidemiological studies? 

      Cheang, Chi Kei (Mastergradsoppgave; Master thesis, 2019-05-14)
      Background: The pressure to share more data and being more transparency of clinical study reports has grown and becomes an important topic in recent years. Before clinical data and clinical results can be shared they must undergo anonymization. How anonymization of clinical data affects the utility is poorly-studied, especially in pharmacoepidemiology. Objective: The aim of the study is to describe ...
    • Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter. 

      Kuresh, Farzane (Master thesis; Mastergradsoppgave, 2015-05-27)
      Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ...
    • Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17 

      Trane, Ingmar (Master thesis; Mastergradsoppgave, 2018-05-25)
      The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...
    • Development of orodispersible films: A new age-appropriate dosage form for children 

      Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
      In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...
    • Large scale cultivation of microalgae at Finnfjord AS: The effect of addition of CO2 and flue gas on lipid production and fatty acid composition 

      Ramskjell, Marte (Master thesis; Mastergradsoppgave, 2018-05-15)
      Background: This master’s thesis was a part of a project involving mass cultivation of microalgae at the smelting plant Finnfjord AS. Microalgae are primary producers of the important omega-3 long-chain polyunsaturated fatty acids EPA and DHA. At Finnfjord, the algae use CO2 from the flue gas for their production of lipid and protein rich biomass. The algal biomass can potentially function well as ...
    • Development of self-eliminating linkers for drug conjugates 

      Nergård, Silje Lillemark (Master thesis; Mastergradsoppgave, 2018-05-15)
      Newly discovered compounds through bioprospecting are screened for cytotoxicity, and many of them are found to be highly toxic. Because they are often not specifically toxic only against cancer cells, they are not further studied. These new compounds could be of further interest by temporarily masking a functional group which regulate the anticancer activity of a cytotoxic compound. This means that ...
    • Synthesis of copper and silver nanoparticles with extracts of berries: A green chemistry approach 

      Løkse, Christoffer Jacobsen (Master thesis; Mastergradsoppgave, 2017-05-15)
      Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ...
    • Molecular modeling of 3D structure of the oxytocin receptor. Discovery of novel oxytocin receptor agonists via molecular docking studies. 

      Antobreh, Gloria Tiwaa (Master thesis; Mastergradsoppgave, 2015-05-15)
      Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ...
    • Large scale cultivation of microalgae at Finnfjord AS: The effect of different storage treatments on lipid and fatty acid stability 

      Aronsen, Simen (Master thesis; Mastergradsoppgave, 2018-05-15)
      The Arctic University of Norway and the ferrosilicon smeltery Finnfjord AS has started a microalgal mass cultivation project where sequestration of CO2 and NOx from factory fumes are used in the production of diatom biomass. Primary application of the produced biomass is fish feed. This requires information regarding lipid content and storage stability. In this study the lipid content, fatty acid ...
    • Improved chronic wound therapy: surface charged deformable liposomes for dermal delivery of curcumin 

      Gagnat, Eivind (Master thesis; Mastergradsoppgave, 2018-05-15)
      Chronic wounds are today representing a major challenge in global healthcare due the difficulty to treat as well as the costs for the society. Therefore, improving chronic wound therapy is an urgent need. Curcumin, a polyphenol compound, has shown to have potential in wound therapy due to its anti-inflammatory, anti-infectious and anti-oxidant properties. However, the poor water solubility, low ...
    • Liposomes as Potential Carrier for Bioactive β2,2- Amino Acid Derivatives - A Feasibility Study 

      Azumah, Joseph (Master thesis; Mastergradsoppgave, 2015-05-13)
      The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ...
    • Quantitative Phosphoprotein Analysis in Adipose Tissue 

      Assignon, Edmund Theodore Fiifi (Master thesis; Mastergradsoppgave, 2016-05-13)
      Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ...
    • Polymer-coated liposomes for hydration of oral mucosa. Investigation of water adsorption, retention, and release properties. 

      Bowitz, Stina Sand (Master thesis; Mastergradsoppgave, 2014-12-15)
      Ailments from a dehydrated mouth may result in problems with food intake, such as chewing and swallowing, with smiling and appearance, and some of them may cause pain. A system to increase hydration of oral mucosa will reduce patient ailments, or the frequency of them, and increase quality of life. The focus of this thesis is to study the potential of polymer coated liposomal systems for hydration ...
    • β-cyclodextrin polymers as cholesterol sequestrating agents 

      Fadeev, Nikolay Olegovich (Master thesis; Mastergradsoppgave, 2018-08-19)
      Summary Elevated serum cholesterol blood levels is one of the central risk factors for cardiovascular diseases. Lowering blood cholesterol have significant impact on lowering cardiovascular disease events. Inhibiting cholesterol absorption in small intestine can significantly lower serum cholesterol levels and thereby - lower cardiovascular events. Β-cyclodextrin (βCD)-dextran polymer is expected ...
    • Bruk av kosttilskudd blant pasienter over 70 år ved Nordlandssykehuset i Bodø 

      Ramstad, Elise Sørensen (Master thesis; Mastergradsoppgave, 2019-05-14)
      Bruk av kosttilskudd er vanlig i den generelle befolkningen. Kosttilskudd er ikke underlagt de samme lover og reguleringer som legemidler, og det er kjent at kosttilskudd kan gi bivirkninger og interagere med legemidler. Eldre mennesker er en spesielt utsatt gruppe for bivirkninger og interaksjoner. Formålet med studien er å kartlegge bruk av kosttilskudd blant pasienter over 70 år, undersøke om ...
    • Isolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp. 

      Ali, Nadia Ghazi (Master thesis; Mastergradsoppgave, 2019-05-15)
      Bacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, ...
    • Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates 

      Valla, Sanne Ekroll (Master thesis; Mastergradsoppgave, 2017-05-15)
      Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ...
    • Reseptpliktige legemidler og samtidig bruk av lavdose naltrekson (LDN) hos pasienter med kronisk inflammatorisk tarmsykdom. En kvasieksperimentell reseptregisterstudie 

      Simonsen, Pia (Master thesis; Mastergradsoppgave, 2017-05-15)
      BAKGRUNN: Naltrekson er en ikke-selektiv opioidantagonist som tradisjonelt brukes til å behandle opioid- og alkoholavhengighet. Lavdose naltrekson (LDN), 3-5 mg/dag, har senere blitt brukt som «off-label» tilleggsbehandling i flere autoimmune sykdommer, inkludert kronisk inflammatorisk tarmsykdom (IBD). FORMÅL: Formålet med denne studien er å undersøke om det er en assosiasjon mellom bruk av LDN og ...