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dc.contributor.authorCahill, James A.
dc.contributor.authorHeintzman, Peter D.
dc.contributor.authorHarris, Kelley
dc.contributor.authorTeasdale, Matthew D.
dc.contributor.authorKapp, Joshua D.
dc.contributor.authorSoares, Andre, E. R.
dc.contributor.authorStirling, Ian
dc.contributor.authorBradley, Daniel
dc.contributor.authorEdwards, Ceiridwen J.
dc.contributor.authorGraim, Kiley
dc.contributor.authorKisleika, Aliaksandr A.
dc.contributor.authorMalev, Alexander V.
dc.contributor.authorMonaghan, Nigel
dc.contributor.authorGreen, Richard E.
dc.contributor.authorShapiro, Beth
dc.date.accessioned2020-09-30T08:43:02Z
dc.date.available2020-09-30T08:43:02Z
dc.date.issued2018-02-20
dc.description.abstractRecent genomic analyses have provided substantial evidence for past periods of gene flow from polar bears (<i>Ursus maritimus</i>) into Alaskan brown bears (<i>Ursus arctos</i>), with some analyses suggesting a link between climate change and genomic introgression. However, because it has mainly been possible to sample bears from the present day, the timing, frequency, and evolutionary significance of this admixture remains unknown. Here, we analyze genomic DNA from three additional and geographically distinct brown bear populations, including two that lived temporally close to the peak of the last ice age. We find evidence of admixture in all three populations, suggesting that admixture between these species has been common in their recent evolutionary history. In addition, analyses of ten fossil bears from the now-extinct Irish population indicate that admixture peaked during the last ice age, whereas brown bear and polar bear ranges overlapped. Following this peak, the proportion of polar bear ancestry in Irish brown bears declined rapidly until their extinction. Our results support a model in which ice age climate change created geographically widespread conditions conducive to admixture between polar bears and brown bears, as is again occurring today. We postulate that this model will be informative for many admixing species pairs impacted by climate change. Our results highlight the power of paleogenomics to reveal patterns of evolutionary change that are otherwise masked in contemporary data.en_US
dc.description.sponsorshipNational Science Foundation The Gorden and Betty Moore Foundation The Irish Research Council for Science Engineering and Technologyen_US
dc.descriptionThis article has been accepted for publication in Molecular Biology and Evolution. Published by Oxford University Press.<p> Submitted manuscript version. Published version available at <a href=https://doi.org/10.1093/molbev/msy018> https://doi.org/10.1093/molbev/msy018</a>.en_US
dc.identifier.citationCahill JA, Heintzman PD, Harris, Teasdale, Kapp JD, Soares AER, Stirling I, Bradley D, Edwards, Graim, Kisleika, Malev, Monaghan, Green RE, Shapiro B. Genomic Evidence of Widespread Admixture from Polar Bears into Brown Bears during the Last Ice Age. Molecular biology and evolution. 2018;35(5):1120-1129en_US
dc.identifier.cristinIDFRIDAID 1588428
dc.identifier.doi10.1093/molbev/msy018
dc.identifier.issn0737-4038
dc.identifier.issn1537-1719
dc.identifier.urihttps://hdl.handle.net/10037/19512
dc.language.isoengen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.journalMolecular biology and evolution
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/295729/EU/Decoding Domesticate DNA in Archaeological Bone and Manuscripts/CODEX/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2018 The Author(s)en_US
dc.subjectVDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Zoogeografi: 486en_US
dc.subjectVDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Zoogeography: 486en_US
dc.subjectVDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økologi: 488en_US
dc.subjectVDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Ecology: 488en_US
dc.subjectgenomicsen_US
dc.subjecthybridizationen_US
dc.subjectancient DNAen_US
dc.subjectursusen_US
dc.subjectpaleogenomicsen_US
dc.subjectadmixtureen_US
dc.titleGenomic Evidence of Widespread Admixture from Polar Bears into Brown Bears during the Last Ice Ageen_US
dc.type.versionsubmittedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePreprinten_US
dc.typeManuskripten_US


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