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dc.contributor.authorGjessing, Mona Cecilie
dc.contributor.authorKrasnov, Aleksei
dc.contributor.authorTimmerhaus, Gerrit
dc.contributor.authorBrun, Svante
dc.contributor.authorAfanasyev, Sergey
dc.contributor.authorDale, Ole Bendik
dc.contributor.authorDahle, Maria K
dc.date.accessioned2020-10-28T14:18:51Z
dc.date.available2020-10-28T14:18:51Z
dc.date.issued2020-09-04
dc.description.abstractThe salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. In this study, we sampled gills from Atlantic salmon presmolts during a natural outbreak of SGPV disease (SGPVD). Samples covered the early phase of infection, the acute mortality phase, the resolving phase of the disease and control fish from the same group and facility. Mortality, the presence and level of SGPV and gill epithelial apoptosis were clearly associated. The gene expression pattern in the acute phase of SGPVD was in tune with the pathological findings and revealed novel transcript-based disease biomarkers, including pro-apoptotic and proliferative genes, along with changes in expression of ion channels and mucins. The innate antiviral response was strongly upregulated in infected gills and chemokine expression was altered. The regenerating phase did not reveal adaptive immune activity within the study period, but several immune effector genes involved in mucosal protection were downregulated into the late phase, indicating that SGPV infection could compromise mucosal defense. These data provide novel insight into the infection mechanisms and host interaction of SGPV.en_US
dc.identifier.citationGjessing, Krasnov, Timmerhaus, Brun, Afanasyev, Dale, Dahle. The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense. Frontiers in Immunology. 2020;11en_US
dc.identifier.cristinIDFRIDAID 1838080
dc.identifier.doi10.3389/fimmu.2020.02154
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/10037/19694
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Immunology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/267491/Norway/Understanding Salmon gill poxvirus disease; an emerging threat for Atlantic salmon farming//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.titleThe Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defenseen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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