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dc.contributor.authorHolter, Jan Cato
dc.contributor.authorPischke, Soeren
dc.contributor.authorde Boer, Eline
dc.contributor.authorLind, Andreas
dc.contributor.authorJenum, Synne
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorTonby, Kristian
dc.contributor.authorBarratt-Due, Andreas
dc.contributor.authorSokolova, Marina
dc.contributor.authorSchjalm, Camilla
dc.contributor.authorChaban, Viktoriia
dc.contributor.authorKolderup, Anette
dc.contributor.authorTran, Trung
dc.contributor.authorTollefsrud Gjølberg, Torleif
dc.contributor.authorSkeie, Linda Gail
dc.contributor.authorHesstvedt, Liv
dc.contributor.authorOrmåsen, Vidar
dc.contributor.authorFevang, Børre
dc.contributor.authorAustad, Cathrine
dc.contributor.authorMuller, Karl Erik
dc.contributor.authorFladeby, Cathrine
dc.contributor.authorHolberg-Petersen, Mona
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorMüller, Fredrik
dc.contributor.authorAukrust, Pål
dc.contributor.authorDudman, Susanne Gjeruldsen
dc.contributor.authorUeland, Thor
dc.contributor.authorAndersen, Jan Terje
dc.contributor.authorLund-Johansen, Fridtjof
dc.contributor.authorHeggelund, Lars
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.contributor.authorMollnes, Tom Eirik
dc.date.accessioned2020-11-09T09:34:35Z
dc.date.available2020-11-09T09:34:35Z
dc.date.issued2020-09-17
dc.description.abstractThe new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated to trigger this detrimental process. The complement system is a key player in innate immunity. Despite a few reports of local complement activation, there is a lack of evidence that the degree of systemic complement activation occurs early in COVID-19 patients, and whether this is associated with respiratory failure. This study shows that a number of complement activation products are systemically, consistently, and long-lastingly increased from admission and during the hospital stay. Notably, the terminal sC5b-9 complement complex was associated with respiratory failure. Thus, complement inhibition is an attractive therapeutic approach for treatment of COVD-19.en_US
dc.identifier.citationHolter, J.C., Pischke, S.E., de Boer, E., Lind, A., Jenum, S., Holten, A.R. ... Mollnes, T.T. (2020). Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients. <i>Proceedings of the National Academy of Sciences of the United States of America, 117</i>(40), 25018-25025.en_US
dc.identifier.cristinIDFRIDAID 1844465
dc.identifier.doi10.1073/pnas.2010540117
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/10037/19791
dc.language.isoengen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/312780/Norway/Norwegian SARS-CoV-2 study – Virological, clinical and immunological characterisation of inpatients during the COVID-19 outbreak//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleSystemic complement activation is associated with respiratory failure in COVID-19 hospitalized patientsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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