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Signalling and bioactive metabolites from Streptomyces sp. RK44

Permanent link
https://hdl.handle.net/10037/19818
DOI
https://doi.org/10.3390/molecules25030460
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Date
2020-01-22
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Fang, Qing; Maglangit, Fleurdeliz; Wu, Linrui; Ebel, Rainer; Kyeremeh, Kwaku; Andersen, Jeanette Hammer; Annang, Frederick; Pérez-Moreno, Guiomar; Reyes, Fernando; Deng, Hai
Abstract
Streptomyces remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of Streptomyces sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites from this strain resulted in the characterization of a new 2-alkyl-4-hydroxymethylfuran carboxamide (AHFA) together with five known compounds, cyclo-(L-Pro-Gly), cyclo-(L-Pro-L-Phe), cyclo-(L-Pro-L-Val), cyclo-(L-Leu-Hyp), and deferoxamine E. AHFA, a methylenomycin (MMF) homolog, exhibited anti-proliferative activity (EC50 = 89.6 µM) against melanoma A2058 cell lines. This activity, albeit weak is the first report amongst MMFs. Furthermore, the putative biosynthetic gene cluster (ahfa) was identified for the biosynthesis of AHFA 1. DFO-E 6 displayed potent anti-plasmodial activity (IC50 = 1.08 µM) against P. falciparum 3D7. High-resolution electrospray ionization mass spectrometry (HR ESIMS) and molecular network assisted the targeted-isolation process, and tentatively identified six AHFA analogues, and six siderophores.
Publisher
MDPI
Citation
Fang, Maglangit, Wu, Ebel, Kyeremeh, Andersen, Annang, Pérez-Moreno, Reyes, Deng. Signalling and bioactive metabolites from Streptomyces sp. RK44. Molecules. 2020;25(3):1-13
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