TRIMs (tripartite motif proteins) constitute a family of ubiquitin E3 ligases that are involved in a variety of cellular processes including autophagy and carcinogenesis. TRIM32 contains an N-terminal RING finger domain, B-box region, a coiled-coil domain and six NHL repeats in the C-terminal region, which are involved in protein dimerization and substrate recognitions. Various mutations in the NHL ...