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dc.contributor.authorSchots, Pauke C.
dc.contributor.authorJansen, Kirsten Maria
dc.contributor.authorMrazek, Jakub
dc.contributor.authorPedersen, Alice Marie
dc.contributor.authorOlsen, Ragnar Ludvig
dc.contributor.authorLarsen, Terje Steinar
dc.date.accessioned2020-12-03T12:22:16Z
dc.date.available2020-12-03T12:22:16Z
dc.date.issued2020-09-09
dc.description.abstractDietary supplementation with calanus oil, a novel wax ester–rich marine oil, has been shown to reduce adiposity in high-fat diet (HFD)–induced obese mice. Current evidence suggests that obesity and its comorbidities are intrinsically linked with unfavorable changes in the intestinal microbiome. Thus, in line with its antiobesity effect, we hypothesized that dietary supplementation with calanus oil should counteract the obesity-related deleterious changes in the gut microbiota. Seven-week-old female C57bl/6J mice received an HFD for 12 weeks to induce obesity followed by 8-week supplementation with 2% calanus oil. For comparative reasons, another group of mice was treated with exenatide, an antiobesogenic glucagon-like peptide-1 receptor agonist. Mice fed normal chow diet or nonsupplemented HFD for 20 weeks served as lean and obese controls, respectively. 16S rRNA gene sequencing was performed on fecal samples from the colon. HFD increased the abundance of the <i>Lactococcus</i> and <i>Leuconostoc</i> genera relative to normal chow diet, whereas abundances of <i>Allobaculum</i> and <i>Oscillospira</i> were decreased. Supplementation with calanus oil led to an apparent overrepresentation of <i>Lactobacillus</i> and <i>Streptococcus</i> and underrepresentation of <i>Bilophila</i>. Exenatide prevented the HFD-induced increase in <i>Lactococcus</i> and caused a decrease in the abundance of <i>Streptococcus</i> compared to the HFD group. Thus, HFD altered the gut microbiota composition in an unhealthy direction by increasing the abundance of proinflammatory genera while reducing those considered health-promoting. These obesity-induced changes were antagonized by both calanus oil and exenatide.en_US
dc.identifier.citationSchots PC, Jansen KM, Mrazek, Pedersen AM, Olsen RL, Larsen TS. Obesity-induced alterations in the gut microbiome in female mice fed a high-fat diet are antagonized by dietary supplementation with a novel, wax ester–rich, marine oil. Nutrition Research. 2020;83:94-107en_US
dc.identifier.cristinIDFRIDAID 1848161
dc.identifier.doihttps://doi.org/10.1016/j.nutres.2020.09.002
dc.identifier.issn0271-5317
dc.identifier.issn1879-0739
dc.identifier.urihttps://hdl.handle.net/10037/19971
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofJansen, K.M. (2021). Modulation of Cardiometabolic Health by Dietary Supplementation with Calanus oil. (Doctoral thesis). <a href=https://hdl.handle.net/10037/22254>https://hdl.handle.net/10037/22254</a>.
dc.relation.journalNutrition Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.titleObesity-induced alterations in the gut microbiome in female mice fed a high-fat diet are antagonized by dietary supplementation with a novel, wax ester–rich, marine oilen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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