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dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHuber-Lang, Markus
dc.date.accessioned2020-12-03T13:03:50Z
dc.date.available2020-12-03T13:03:50Z
dc.date.issued2020-07-21
dc.description.abstractSepsis as life-threatening organ dysfunction caused by microorganisms represents a dreadful challenge for the immune system. The role of the complement system as major column of innate immunity has been extensively studied in various sepsis models, but its translational value remains in the dark. Complement activation products, such as C3a and C5a, and their corresponding receptors provide useful diagnostic tools and promising targets to improve organ function and outcome. However, a monotherapeutic complement intervention irrespective of the current immune function seems insufficient to reverse the complex sepsis mechanisms. Indeed, sepsis-induced disturbances of cross talking complement, coagulation, and fibrinolytic cascades lead to systemic ‘thromboinflammation’, ultimately followed by multiple-organ failure. We propose to reliably monitor the complement function in the patient and to re-establish the immune balance by patient-tailored combined therapies, such as complement and Toll-like receptor inhibition. Our working hypothesis aims at blocking the ‘explosive’ innate immune recognition systems early on before downstream mediators are released and the inflammatory response becomes irreversible, a strategy that we name ‘upstream approach’.en_US
dc.identifier.citationMollnes, Huber-Lang. Complement in sepsis — when science meets clinics. FEBS Letters. 2020;594(16):2621-2632en_US
dc.identifier.cristinIDFRIDAID 1821621
dc.identifier.doi10.1002/1873-3468.13881
dc.identifier.issn0014-5793
dc.identifier.issn1873-3468
dc.identifier.urihttps://hdl.handle.net/10037/19975
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalFEBS Letters
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleComplement in sepsis — when science meets clinicsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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