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dc.contributor.authorBruserud, Ingvild Særvold
dc.contributor.authorRoelants, Mathieu
dc.contributor.authorOehme, Ninnie
dc.contributor.authorMadsen, Andre
dc.contributor.authorEide, Geir Egil
dc.contributor.authorBjerknes, Robert
dc.contributor.authorRosendahl, Karen
dc.contributor.authorJuliusson, Petur Benedikt
dc.date.accessioned2020-12-30T09:38:21Z
dc.date.available2020-12-30T09:38:21Z
dc.date.issued2020-03-06
dc.description.abstract<i>Context</i> - Discriminating adipose and glandular tissue is challenging when clinically assessing breast development. Ultrasound facilitates staging of pubertal breast maturation (US B), but has not been systematically compared to Tanner breast (Tanner B) staging, and no normative data have been reported.<p> <p><i>Objective</i> - To present normative references for US B along with references for Tanner B, pubic hair (PH), and menarche.<p> <p><i>Design, Setting, and Participants</i> - A cross-sectional sample of 703 healthy girls aged 6 to 16 years were examined.<p> <p><i>Main Outcome Measures</i> - Breast development was determined with US B and Tanner B staging. Tanner PH and menarcheal status were recorded. The age distributions of entry in US B, Tanner B, and PH stages and menarche were estimated with generalized linear and generalized additive models with a probit link. Method agreement was tested with weighted Cohen’s kappa.<p> <p><i>Results</i> - The median (±2SD) ages for thelarche, US B2 and Tanner B2, were 10.2 (7.7, 12.8) and 10.4 (8.0, 12.7) years. The median (±2SD) ages at Tanner PH2 and menarche were 10.9 (8.5, 13.3) and 12.7 (11.0, 16.2) years. Cohen’s kappa of agreement (95% confidence interval) between US B and Tanner B was 0.87 (0.85–0.88). When the methods disagreed, US B was usually more advanced.<p> <p><i>Conclusion</i> - Thelarche occurred at a slightly younger age when assessed with ultrasound compared to clinical Tanner staging, although the 2 methods had a very good agreement when determining pubertal breast maturation. A significant decrease of 2.8 months in age at menarche was observed during the past decade in Norwegian girls.en_US
dc.identifier.citationBruserud IS, Roelants M, Oehme NHB, Madsen AG, Eide GE, Bjerknes R, Rosendahl K, Juliusson P. References for ultrasound staging of breast maturation, tanner breast staging, pubic hair, and menarche in Norwegian girls. Journal of Clinical Endocrinology and Metabolism. 2020;105(5):1599-1607en_US
dc.identifier.cristinIDFRIDAID 1812430
dc.identifier.doi10.1210/clinem/dgaa107
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.urihttps://hdl.handle.net/10037/20159
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalJournal of Clinical Endocrinology and Metabolism
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© Endocrine Society 2020.en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleReferences for ultrasound staging of breast maturation, tanner breast staging, pubic hair, and menarche in Norwegian girlsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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