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No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study

Permanent lenke
https://hdl.handle.net/10037/20183
DOI
https://doi.org/10.1186/s12902-020-00630-4
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article.pdf (492.9Kb)
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Dato
2020-10-01
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Raknes, Guttorm; Småbrekke, Lars
Sammendrag
Background - Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism.

Methods - We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. Study participants were identified by using reimbursement codes for hypothyroidism. Cumulative dispensed Defined Daily Doses and the number of users of triiodothyronine (T3) and levothyroxine (LT4) 1 year before and after the first LDN prescription was compared in three groups based on LDN exposure.

Results - We identified 898 patients that met the inclusion criteria. There was no association between starting LDN and the subsequent dispensing of thyroid hormones. If anything, there was a tendency towards increasing LT4 consumption with increasing LDN exposure.

Conclusion - The results of this study do not support claims of efficacy of LDN in hypothyroidism.

Forlag
BMC
Sitering
Raknes, Småbrekke. No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study. BMC Endocrine Disorders. 2020;20(1)
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Copyright 2020 The Author(s)

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