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dc.contributor.authorHindenes, Lars Bakke
dc.contributor.authorHåberg, Asta Kristine
dc.contributor.authorMathiesen, Ellisiv B
dc.contributor.authorVangberg, Torgil Riise
dc.date.accessioned2021-01-28T22:31:50Z
dc.date.available2021-01-28T22:31:50Z
dc.date.issued2020-12-11
dc.description.abstract<p><i>Objective - </i>The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. <p><i>Methods - </i>In a cross-sectional population sample of 1751 people (age 40–84 years, 46.4% men), we used an automated method to segment WMH using T1-weighted and T2-weighted fluid-attenuated inversion recovery image obtained at 3T. CoW variants were classified from time-of-flight scans, also at 3T. WMH risk factors, including age, sex, smoking and blood pressure, were obtained from questionnaires and clinical examinations. We used linear regression to examine whether people with incomplete CoW variants had greater volumes of deep WMH (DWMH) and periventricular WMH (PWMH) compared to people with the complete CoW, correcting for WMH risk factors. <p><i>Results - </i>Participants with incomplete CoW variants did not have significantly higher DWMH or PWMH volumes than those with complete CoW when accounting for risk factors. Age, pack-years smoking, and systolic blood pressure were risk factors for increased DWMH and PWMH volume. Diabetes was a unique risk factor for increased PWMH volume. <p><i>Conclusion - </i>Incomplete CoW variants do not appear to be risk factors for WMH in the general population.en_US
dc.identifier.citationHindenes, Håberg, Mathiesen, Vangberg. An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study. Journal of Neurological Sciences. 2020;420(117268)en_US
dc.identifier.cristinIDFRIDAID 1861208
dc.identifier.doi10.1016/j.jns.2020.117268
dc.identifier.issn1302-1664
dc.identifier.urihttps://hdl.handle.net/10037/20500
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Neurological Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752en_US
dc.subjectThe Tromsø Studyen_US
dc.subjectTromsøundersøkelsenen_US
dc.titleAn incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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