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dc.contributor.authorBjõrk, Jonas
dc.contributor.authorNyman, Ulf
dc.contributor.authorCourbebaisse, Marie
dc.contributor.authorCouzi, Lionel
dc.contributor.authorDalton, R. Neil
dc.contributor.authorDubourg, Laurence
dc.contributor.authorEbert, Natalie
dc.contributor.authorEriksen, Bjõrn O.
dc.contributor.authorGaillard, Francois
dc.contributor.authorGarrouste, Cyril
dc.contributor.authorGrubb, Anders
dc.contributor.authorHansson, Magnus
dc.contributor.authorJacquemont1, Lola
dc.contributor.authorJones, Ian
dc.contributor.authorKamar, Nassim
dc.contributor.authorLamb, Edmund J.
dc.contributor.authorLegendre, Christophe
dc.contributor.authorLittmann, Karin
dc.contributor.authorMariat, Christophe
dc.contributor.authorMelsom, Toralf
dc.contributor.authorRostaing, Lionel
dc.contributor.authorRule, Andrew D.
dc.contributor.authorSchaeffner, Elke
dc.contributor.authorSundin, Per-Ola
dc.contributor.authorTurner, Stephen
dc.contributor.authorÅkesson, Anna
dc.contributor.authorDelanaye, Pierre
dc.contributor.authorPottel, Hans
dc.date.accessioned2021-04-09T12:17:34Z
dc.date.available2021-04-09T12:17:34Z
dc.date.issued2020-06-13
dc.description.abstractBackground - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods - In a cross-sectional analysis covering the years 2003–17, CKD-EPI was validated against measured GFR (mGFR; using various tracer methods) in patients with high likelihood of chronic kidney disease (CKD; five CKD cohorts, n = 8365) and in patients with low likelihood of CKD (six community cohorts, n = 6759). Comparisons were made with the Lund–Malmö revised equation (LMR) and the Full Age Spectrum equation.<p> <p>Results - 7In patients aged 18–39 years old, CKD-EPI overestimated GFR with 5.0–16 mL/min/1.73 m2 in median in both cohort types at mGFR levels <120 mL/min/1.73 m2. LMR had greater accuracy than CKD-EPI in the CKD cohorts (P30, the percentage of estimated GFR within 30% of mGFR, 83.5% versus 76.6%). CKD-EPI was generally the most accurate equation in the community cohorts, but all three equations reached P30 above the Kidney Disease Outcomes Quality Initiative benchmark of 90%.<p> <p>Conclusions - None of the evaluated equations made optimal use of available data. Prospects for improved GFR estimation procedures based on creatinine exist, particularly in young adults and in settings where patients with suspected or manifest CKD are investigated.en_US
dc.identifier.citationMelsom T, Eriksen BO. Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study. Clinical Kidney Journal. 2020en_US
dc.identifier.cristinIDFRIDAID 1881211
dc.identifier.doihttps://doi.org/10.1093/ckj/sfaa039
dc.identifier.issn2048-8505
dc.identifier.issn2048-8513
dc.identifier.urihttps://hdl.handle.net/10037/20840
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalClinical Kidney Journal
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleProspects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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