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dc.contributor.authorMarquardt, Lynn Anne
dc.contributor.authorKusztrits, Isabella
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorHugdahl, Kenneth
dc.contributor.authorSpecht, Karsten
dc.contributor.authorHirnstein, Marco
dc.date.accessioned2021-04-22T08:11:47Z
dc.date.available2021-04-22T08:11:47Z
dc.date.issued2020-08-03
dc.description.abstractThe underlying neural mechanisms of transcranial direct current stimulation (tDCS), especially beyond the primary motor cortex, remain unclear. Several studies examined tDCS effects on either functional activity, neurotransmitters or behavior but few investigated those aspects together to reveal how the brain responds to tDCS. The objective is to elucidate the underlying mechanisms of tDCS using a multimodal approach that extends from behavioral to neurotransmitter levels of explanation. Thirty‐two healthy participants performed an auditory dichotic listening task at two visits, one session with sham and one session with real tDCS (2 mA) while simultaneously undergoing functional magnetic resonance imaging (fMRI). The anode and cathode were placed over the left temporo‐parietal cortex (TPC) and dorsolateral prefrontal cortex, respectively. Before and after simultaneous dichotic listening/fMRI/tDCS, combined glutamate and glutamine (Glx) and myo‐inositol levels were assessed in the stimulated areas. While fMRI and dichotic listening showed expected functional activity and behavioral effects, neither method demonstrated differences between real and sham stimulation. Glx only showed a statistical trend towards higher levels after real tDCS in both stimulated brain areas. There were no significant correlations between behavior and Glx. Despite a reasonable sample size, electrical field strength, and replication of behavioral and functional activity results, tDCS had little to no effect on dichotic listening, Glx, and functional activity. The study emphasizes that findings about the underlying neural mechanisms of the primary motor cortex cannot simply be generalized to other brain areas. Particularly, the TPC might be less sensitive to tDCS. Moreover, the study demonstrates the general feasibility of multimodal approaches.en_US
dc.identifier.citationMarquardt, Kusztrits, Craven, Hugdahl, Specht, Hirnstein. A multimodal study of the effects of tDCS on dorsolateral prefrontal and temporo-parietal areas during dichotic listening. European Journal of Neuroscience. 2020:1-11en_US
dc.identifier.cristinIDFRIDAID 1854105
dc.identifier.doi10.1111/ejn.14932
dc.identifier.issn0953-816X
dc.identifier.issn1460-9568
dc.identifier.urihttps://hdl.handle.net/10037/20992
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalEuropean Journal of Neuroscience
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/693124/EU/Perception of voices that do not exist: Tracking the temporal signatures of auditory hallucinations/ONOFF/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleA multimodal study of the effects of tDCS on dorsolateral prefrontal and temporo-parietal areas during dichotic listeningen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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