Blar i forfatter Mastergradsoppgaver for lærerutdanning i realfag "Martinsen, Nina Nevjar"
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Effects of single and multiple OXA-48 mutants on enzyme activity, stability, and structure-activity relationship. Evolutionary consequences of antibiotic resistance development caused by OXA-48
Martinsen, Nina Nevjar (Master thesis; Mastergradsoppgave, 2022-06-02)Antimicrobial resistance, primarily caused by the overuse of antimicrobials such as antibiotics, is becoming an increasing concern to public health. To that end, the global spread of the -lactamase OXA-48 is worrisome, as it readily catalyzes the hydrolysis of -lactam drugs, such as penicillins as well as our “last resort” carbapenems. On the contrary, OXA-48 exhibits only limited catalytic activity ...