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High expression of microRNA‑126 relates to favorable prognosis for colon cancer patients

Permanent lenke
https://hdl.handle.net/10037/21662
DOI
https://doi.org/10.1038/s41598-021-87985-3
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Åpne
article.pdf (1.215Mb)
Publisert versjon (PDF)
Dato
2021-05-05
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Selven, Hallgeir; Rasmussen Busund, Lill-Tove; Bremnes, Roy M.; Andersen, Sigve; Kilvær, Thomas Karsten
Sammendrag
miR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I–III colon cancer was retrospectively collected and tissue microarrays were constructed. miR-126 expression was evaluated by in situ hybridization and analyzed using digital pathology. To isolate the compartment specific contribution of miR-126, tumor and adjacent tumor stroma were considered separately. In univariate analyses, high expression of miR-126 in tumor and stroma was related to increased disease-specific survival (p < 0.001 and p = 0.005, respectively). In multivariate analyses, high miR-126 expression in tumor remained a significant independent predictor of improved disease-specific survival (HR = 0.42, CI 0.23–0.75, p = 0.004). Within different TNM-stages there was a tendency towards the same results, but with statistically significant results in stage II only (p = 0.007). High expression of miR-126 is an independent positive prognostic factor in stage I–III colon cancer. This finding may be used to identify patients in need of adjuvant chemotherapy.
Er en del av
Selven, H. (2023). Assessing new prognostic biomarkers in resected colon cancer patients. (Doctoral thesis). https://hdl.handle.net/10037/29356.
Forlag
Nature Research
Sitering
Selven, Rasmussen Busund, Bremnes, Andersen, Kilvær. High expression of microRNA‑126 relates to favorable prognosis for colon cancer patients. Scientific Reports. 2021
Metadata
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2021 The Author(s)

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