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dc.contributor.authorBaiju, Nikita
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorSætrom, Pål
dc.contributor.authorNøst, Therese Haugdahl
dc.date.accessioned2021-07-06T11:53:24Z
dc.date.available2021-07-06T11:53:24Z
dc.date.issued2021-01-12
dc.description.abstractActive smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes (DEGs) in whole-blood among ever smokers. This study analysed microarray-based gene expression profiles from whole-blood samples according to smoking status and quantitative measures of smoking exposure among cancer-free women (n = 1708) in the Norwegian Women and Cancer postgenome cohort. When compared with never smokers and former smokers, current smokers had 911 and 1082 DEGs, respectively and their biological functions could indicate systemic impacts of smoking. LRRN3 was associated with smoking status with the lowest FDR-adjusted p-value. When never smokers and all former smokers were compared, no DEGs were observed, but LRRN3 was differentially expressed when never smokers were compared with former smokers who quit smoking ≤ 10 years ago. Further, LRRN3 was positively associated with smoking intensity, pack-years, and comprehensive smoking index score among current smokers; and negatively associated with time since cessation among former smokers. Consequently, LRRN3 expression in whole-blood is a molecular signal of smoking exposure that could supplant self-reported smoking data in further research targeting blood-based markers related to the health effects of smoking.en_US
dc.identifier.citationBaiju, Sandanger, Sætrom, Nøst. Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort. Scientific Reports. 2021;11(1):1-13en_US
dc.identifier.cristinIDFRIDAID 1905141
dc.identifier.doi10.1038/s41598-020-80158-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/21771
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.ispartofBaiju, N. (2023). Gene expression in blood and cancer risk factors – Investigating associations of blood gene expression with Smoking, BMI, and Menopause in the Norwegian Women and Cancer (NOWAC) postgenome cohort. (Doctoral thesis). <a href=https://hdl.handle.net/10037/31426>https://hdl.handle.net/10037/31426</a>.
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleGene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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