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dc.contributor.authorArnstad, Ellen Dalen
dc.contributor.authorGlerup, Mia
dc.contributor.authorRypdal, Veronika Gjertsen
dc.contributor.authorPeltoniemi, Suvi
dc.contributor.authorFasth, Anders
dc.contributor.authorNielsen, Susan
dc.contributor.authorZak, Marek
dc.contributor.authorAalto, Kristiina
dc.contributor.authorBerntson, Lillemor
dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorHerlin, Troels
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorRygg, Marite
dc.date.accessioned2021-07-07T11:08:30Z
dc.date.available2021-07-07T11:08:30Z
dc.date.issued2021-03-12
dc.description.abstractBackground: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1–7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used. Results: Among 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease-modifying anti-rheumatic drugs (DMARDs)/ biologics/systemic steroids. In contrast, participants without these challenges, had fatigue scores similar to controls. Active disease assessed at all three time points (baseline, 8-year and 18-year follow-up) was associated with higher mean fatigue score and higher percentage of severe fatigue compared to disease courses characterized by periods of inactive disease. Predictors of fatigue at the 18-year follow-up were female sex and diagnostic delay of ≥6 months at baseline, and also pain, self-reported poor health, active disease, and previous/ongoing use of DMARDs/ biologics at 8 years.en_US
dc.identifier.citationArnstad, Glerup, Rypdal, Peltoniemi, Fasth, Nielsen, Zak, Aalto, Berntson, Nordal, Herlin, Romundstad, Rygg. Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort. Pediatric Rheumatology. 2021;19en_US
dc.identifier.cristinIDFRIDAID 1916816
dc.identifier.doi10.1186/s12969-021-00499-0
dc.identifier.issn1546-0096
dc.identifier.urihttps://hdl.handle.net/10037/21814
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalPediatric Rheumatology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleFatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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