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Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons

Permanent lenke
https://hdl.handle.net/10037/21871
DOI
https://doi.org/10.1177/1934578X21996180
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article.pdf (1.200Mb)
Publisert versjon (PDF)
Dato
2021-02-21
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Østnes Hansen, Kine; Hansen, Ida Kristine Østnes; Richard, Céline Sarah Marine; Jenssen, Marte; Andersen, Jeanette Hammer; Hansen, Espen Holst
Sammendrag
Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan Securiflustra securifrons was found to be active against the human pathogenic bacterium Streptococcus agalactiae (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H – J (4, 5, and 1-3) and the attempt to deconvolute the mode of action of 1.
Er en del av
Richard, C.S.M. (2024). Engineering novel bacterial biosensors for the characterization of membrane active natural products. (Doctoral thesis). https://hdl.handle.net/10037/33610
Forlag
SAGE Publications
Sitering
Østnes Hansen KØH, Hansen IKØ, Richard CSM, Jenssen M, Andersen JH, Hansen E. H.. Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons. Natural Product Communications. 2021;16(2):1-8
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  • Artikler, rapporter og annet (Norges fiskerihøgskole) [1053]
Copyright 2021 The Author(s)

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