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dc.contributor.authorCheng, Socheat
dc.contributor.authorSiddiqui, Tahreem Ghazal
dc.contributor.authorGossop, Michael
dc.contributor.authorWyller, Torgeir Bruun
dc.contributor.authorKristoffersen, Espen Saxhaug
dc.contributor.authorLundqvist, Anders Christofer
dc.date.accessioned2021-07-14T07:01:17Z
dc.date.available2021-07-14T07:01:17Z
dc.date.issued2021-02-18
dc.description.abstract<i>Background</i> - Multimorbidity and prolonged use of addictive medications are prevalent among older patients, and known to increase the risk of adverse drug events. Yet, the relationship between these two entities has remained understudied.<br><br> <i>Aims</i> - This study explored the association between multimorbidity burden and prolonged use of addictive medications in geriatric patients, adjusted for clinically important covariates. Furthermore, we identified comorbidity patterns in prolonged users.<br><br> <i>Methods</i> - We conducted a cross-sectional study on a consecutive sample of 246 patients, aged 65–90 years, admitted to a large public university hospital in Norway. We defined prolonged use of addictive medications as using benzodiazepines, opioids and/or z-hypnotics beyond the duration recommended by clinical guidelines (≥ 4 weeks). Multimorbidity was assessed with the Cumulative Illness Rating Scale for Geriatrics (CIRS-G), based on diagnoses made by independent physicians.<br><br> <i>Results</i> - Compared to non-prolonged use, prolonged use was significantly more common among patients who had psychiatric (19/27, 70%), liver (19/22, 86%), upper gastrointestinal tract (21/32, 66%), musculoskeletal (52/96, 54%), or nervous system disorders (46/92, 50%). Patients with prolonged use had a higher multimorbidity burden than those without such use (CIRS-G score, mean = 7.7, SD = 2.7 versus mean = 4.6, SD = 2.2, <i>p</i> < 0.001). Multivariable logistic regression indicated a significant association between multimorbidity burden and prolonged addictive medication use (OR = 1.72, 95% CI 1.42–2.08). Predictive margins postestimation showed a systematic increase in the predicted CIRS-G scores when the number of addictive drug used increases.<br><br> <i>Conclusions</i> - Multimorbidity is strongly associated with prolonged use of addictive medications. Multiple substance use may aggravate disease burden of older patients.en_US
dc.identifier.citationCheng, Siddiqui, Gossop, Wyller, Kristoffersen, Lundqvist. The patterns and burden of multimorbidity in geriatric patients with prolonged use of addictive medications. Aging Clinical and Experimental Research. 2021en_US
dc.identifier.cristinIDFRIDAID 1891557
dc.identifier.doi10.1007/s40520-021-01791-5
dc.identifier.issn1594-0667
dc.identifier.issn1720-8319
dc.identifier.urihttps://hdl.handle.net/10037/21873
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalAging Clinical and Experimental Research
dc.relation.projectIDNorges forskningsråd: 256431en_US
dc.relation.projectIDUniversitetet i Oslo: 2019/13316 HEIDIFECen_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HELSEVEL-H/256431/Norway/HOW DO WE PROVIDE BETTER, SAFER AND MORE COST-EFFECTIVE CARE PATHWAYS FOR OLDER PEOPLE?//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Geriatri: 778en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Geriatrics: 778en_US
dc.subjectVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Klinisk farmakologi: 739en_US
dc.subjectVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Clinical pharmacology: 739en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Klinisk psykologi: 262en_US
dc.subjectVDP::Social sciences: 200::Psychology: 260::Clinical psychology: 262en_US
dc.titleThe patterns and burden of multimorbidity in geriatric patients with prolonged use of addictive medicationsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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