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dc.contributor.authorToft, Helge
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorTilden, Terje
dc.contributor.authorBolstad, Ingeborg
dc.contributor.authorLien, Lars
dc.date.accessioned2021-07-14T07:31:25Z
dc.date.available2021-07-14T07:31:25Z
dc.date.issued2021-04-27
dc.description.abstract<i>Objective</i>: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient treatment.<br><br> <i>Methods</i>: Patients in treatment for serious non-psychotic mental disorders were recruited at the beginning of their treatment stay at a psychiatric centre in Norway. Ninety patients submitted serum samples and filled out the Hopkins Symptom Checklist-90 Revised Global Severity Index (HSCL-90R GSI) questionnaire during their mainstay and at a follow-up stay 1 year after discharge. Of these patients, 33 were diagnosed with PTSD, 48 with anxiety, depression, or eating disorder, while 9 patients had missing data. The patients were diagnosed using the Mini-International Neuropsychiatric Interview (MINI).<br><br> <i>Results</i>: At the follow-up stay (T<sub>3</sub>), PTSD patients had higher levels of GSI scores than non-PTSD patients (<i>p</i> = 0.048). These levels were unchanged from the year before (T<sub>2</sub>) in both groups. The levels of circulating cytokines/chemokine did not differ between the PTSD and non-PTSD patients at T<sub>3</sub>. At T<sub>2</sub>, however, the PTSD and non-PTSD groups exhibited different levels of interleukin 1β (IL-1β) (<i>p</i> = 0.053), IL-1RA (<i>p</i> = 0.042), and TNF-α (<i>p</i> = 0.037), with the PTSD patients having the higher levels.<br><br> <i>Conclusion</i>: Despite exhibiting different mental distress scores, the PTSD and non-PTSD patients did not differ regarding levels of circulating inflammatory markers at 1-year follow-up.en_US
dc.identifier.citationToft HT, Bramness JG, Tilden TT, Bolstad I, Lien L. Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment.. Acta Neuropsychiatrica. 2021en_US
dc.identifier.cristinIDFRIDAID 1910980
dc.identifier.doi10.1017/neu.2021.11
dc.identifier.issn0924-2708
dc.identifier.issn1601-5215
dc.identifier.urihttps://hdl.handle.net/10037/21876
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.relation.journalActa Neuropsychiatrica
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titlePersistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatmenten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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