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dc.contributor.authorAmundsen, Siri
dc.contributor.authorNordeng, Hedvig
dc.contributor.authorNordeng, Hedvig Marie Egeland
dc.contributor.authorFuskevåg, Ole Martin
dc.contributor.authorNordmo, Elisabet
dc.contributor.authorNordmo, Elisabet N
dc.contributor.authorSager, Georg
dc.contributor.authorSpigset, Olav
dc.date.accessioned2021-08-23T11:18:37Z
dc.date.available2021-08-23T11:18:37Z
dc.date.issued2021-03-17
dc.description.abstractClinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, each participant collected seven breast milk samples at predefined intervals up to 24 hours after dose. Triptan concentrations in milk were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Infant drug exposure was estimated by calculating the relative infant dose (RID). Twenty-two breast milk sample sets were obtained for sumatriptan (n = 8), rizatriptan (n = 5), zolmitriptan (n = 4), eletriptan (n = 3), almotriptan (n = 1) and naratriptan (n = 1). Based on the average concentration in milk throughout the day, estimated mean RIDs (with range in parenthesis) were as follows: eletriptan 0.6% (0.3%-0.8%), sumatriptan 0.7% (0.2%-1.8%), rizatriptan 0.9% (0.3%-1.4%), almotriptan 1.8% (-), zolmitriptan 2.1% (0.7%-5.3%) and naratriptan 5.0% (-). Infant drug exposure through breastfeeding appears to be low and indicates that use of the triptans in this study is compatible with breastfeeding. Naratriptan may not be first choice in breastfeeding mothers initiating triptans during the neonatal period.en_US
dc.identifier.citationAmundsen S, Nordeng, Nordeng HME, Fuskevåg O, Nordmo, Nordmo En, Sager gs, Spigset O. Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. Basic & Clinical Pharmacology & Toxicology. 2021;128(6):1-10en_US
dc.identifier.cristinIDFRIDAID 1918022
dc.identifier.doi10.1111/bcpt.13579
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.urihttps://hdl.handle.net/10037/22210
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalBasic & Clinical Pharmacology & Toxicology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleTransfer of triptans into human breast milk and estimation of infant drug exposure through breastfeedingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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