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dc.contributor.authorWidding-Havneraas, Tarjei
dc.contributor.authorChaulagain, Ashmita
dc.contributor.authorLyhmann, Ingvild
dc.contributor.authorZachrisson, Henrik Daae
dc.contributor.authorElwert, Felix
dc.contributor.authorMarkussen, Simen
dc.contributor.authorMcDaid, David
dc.contributor.authorMykletun, Arnstein
dc.date.accessioned2021-10-26T07:03:59Z
dc.date.available2021-10-26T07:03:59Z
dc.date.issued2021-06-11
dc.description.abstract<i>Objective</i> - Preference-based instrumental variables (PP IV) designs can identify causal effects when patients receive treatment due to variation in providers’ treatment preference. We offer a systematic review and methodological assessment of PP IV applications in health research.<br><br> <i>Study Design and Setting</i> - We included studies that applied PP IV for evaluation of any treatment in any population in health research (PROSPERO: CRD42020165014). We searched within four databases (Medline, Web of Science, ScienceDirect, SpringerLink) and four journals (including full-text and title and abstract sources) between January 1, 1998, and March 5, 2020. We extracted data on areas of applications and methodology, including assumptions using Swanson and Hernan's (2013) guideline.<br><br> <i>Results</i> - We included 185 of 1087 identified studies. The use of PP IV has increased, being predominantly used for treatment effects in cancer, cardiovascular disease, and mental health. The most common PP IV was treatment variation at the facility-level, followed by physician- and regional-level. Only 12 percent of applications report the four main assumptions for PP IV. Selection on treatment may be a potential issue in 46 percent of studies.<br><br> <i>Conclusion</i> - The assumptions of PP IV are not sufficiently reported in existing work. PP IV-studies should use reporting guidelines.en_US
dc.identifier.citationWidding-Havneraas, Chaulagain, Lyhmann, Zachrisson, Elwert, Markussen, McDaid, Mykletun. Preference-based instrumental variables in health research rely on important and underreported assumptions: a systematic review. Journal of Clinical Epidemiology. 2021en_US
dc.identifier.cristinIDFRIDAID 1924463
dc.identifier.doi10.1016/j.jclinepi.2021.06.006
dc.identifier.issn0895-4356
dc.identifier.issn1878-5921
dc.identifier.urihttps://hdl.handle.net/10037/22822
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Clinical Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titlePreference-based instrumental variables in health research rely on important and underreported assumptions: a systematic reviewen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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