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dc.contributor.authorLergenmuller, Simon
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorRobsahm, Trude Eid
dc.contributor.authorGreen, Adèle C.
dc.contributor.authorLund, Eiliv
dc.contributor.authorRueegg, Corina Silvia
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2021-11-18T10:01:37Z
dc.date.available2021-11-18T10:01:37Z
dc.date.issued2021-08-11
dc.description.abstractEvidence on sunscreen use and cutaneous squamous cell carcinoma (cSCC) risk is limited. Most studies have not taken sun protection factor (SPF) into consideration and used nonusers of sunscreen as the reference group. Nonusers are likely a priori at lower cSCC risk than users. No study has investigated the effect of high- versus low-SPF sunscreens on cSCC, appropriately adjusting for time-varying confounding. Using data from the Norwegian Women and Cancer Study (1991–2016), we investigated whether use of SPF ≥15 versus SPF <15 sunscreens reduces cSCC risk. We used a marginal structural Cox proportional hazards model with inverse probability of treatment and censoring weights to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During follow-up of 148,781 women (mean follow-up, 14.3 years), 653 women were diagnosed with cSCC. The effect on cSCC risk of sunscreens with SPF ≥15 versus SPF <15 was close to the null when used at any latitudes (HR = 1.02, 95% CI: 0.82, 1.27) and when used in lower-latitude settings (HR = 1.05, 95% CI: 0.84, 1.32). In conclusion, we found no indication that sunscreens with SPF ≥15 reduced Norwegian women’s cSCC risk more than sunscreens with SPF <15, suggesting that either there is no difference in their effects long-term or the difference is diluted by incorrect application.en_US
dc.identifier.citationLergenmuller S, Ghiasvand R, Robsahm R, Green AC, Lund e, Rueegg CS, Veierød MB. Sunscreens With High Versus Low Sun Protection Factor and Cutaneous Squamous Cell Carcinoma Risk: A Population-Based Cohort Study. American Journal of Epidemiology. 2021en_US
dc.identifier.cristinIDFRIDAID 1953509
dc.identifier.doihttps://doi.org/10.1093/aje/kwab216
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.urihttps://hdl.handle.net/10037/23061
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalAmerican Journal of Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleSunscreens With High Versus Low Sun Protection Factor and Cutaneous Squamous Cell Carcinoma Risk: A Population-Based Cohort Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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