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dc.contributor.authorSchneider, Yannik Karl-Heinz
dc.date.accessioned2021-11-19T14:15:15Z
dc.date.available2021-11-19T14:15:15Z
dc.date.issued2021-07-10
dc.description.abstractThe problem of antibiotic resistance has become a challenge for our public health and society; it has allowed infectious diseases to re-emerge as a risk to human health. New antibiotics that are introduced to the market face the rise of resistant pathogens after a certain period of use. The relatively fast development of resistance against some antibiotics seems to be closely linked to their microbial origin and function in nature. Antibiotics in clinical use are merely products of microorganisms or derivatives of microbial products. The evolution of these antimicrobial compounds has progressed with the evolution of the respective resistance mechanisms in microbes for billions of years. Thus, antimicrobial resistance genes are present within the environment and can be taken up by pathogens through horizontal gene transfer. Natural products from bacteria are an important source of leads for drug development, and microbial natural products have contributed the most antibiotics in current clinical use. Bioprospecting for new antibiotics is a labor-intensive task as obstacles such as redetection of known compounds and low compound yields consume significant resources. The number of bacterial isolates one can theoretically investigate for new secondary metabolites is, on the other hand, immense. Therefore, the available capacity for biodiscovery should be focused on the most promising sources for chemical novelty and bioactivity, employing the appropriate scientific tools. This can be done by first looking into under- or unexplored environments for bacterial isolates and by focusing on the promising candidates to reduce the number of subjects.en_US
dc.identifier.citationSchneider. Bacterial Natural Product Drug Discovery for New Antibiotics: Strategies for Tackling the Problem of Antibiotic Resistance by Efficient Bioprospecting. Antibiotics. 2021en_US
dc.identifier.cristinIDFRIDAID 1950368
dc.identifier.doi10.3390/antibiotics10070842
dc.identifier.issn2079-6382
dc.identifier.urihttps://hdl.handle.net/10037/23091
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalAntibiotics
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/MarPipe/721421/Norway/Improving the flow in the pipeline of the next generation of marine biodiscovery scientists//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectAntibiotika / Antibioticsen_US
dc.subjectAntibiotika resistens / Antibiotic resistanceen_US
dc.subjectBioaktive naturstoffer / Bioactive natural productsen_US
dc.subjectLegemidler / Drug developmenten_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleBacterial Natural Product Drug Discovery for New Antibiotics: Strategies for Tackling the Problem of Antibiotic Resistance by Efficient Bioprospectingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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