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dc.contributor.authorOkoli, Arinze Stanley
dc.contributor.authorBlix, Torill Pauline Bakkelund
dc.contributor.authorMyhr, Anne I
dc.contributor.authorXu, Wenteng
dc.contributor.authorXu, Xiadong
dc.date.accessioned2021-12-03T09:52:06Z
dc.date.available2021-12-03T09:52:06Z
dc.date.issued2021-07-25
dc.description.abstractAquaculture is becoming the primary source of seafood for human diets, and farmed fish aquaculture is one of its fastest growing sectors. The industry currently faces several challenges including infectious and parasitic diseases, reduced viability, fertility reduction, slow growth, escapee fish and environmental pollution. The commercialization of the growth-enhanced AquAdvantage salmon and the CRISPR/Cas9-developed tilapia (Oreochromis niloticus) proffers genetic engineering and genome editing tools, e.g. CRISPR/Cas, as potential solutions to these challenges. Future traits being developed in different fish species include disease resistance, sterility, and enhanced growth. Despite these notable advances, off-target effect and non-clarification of trait-related genes among other technical challenges hinder full realization of CRISPR/Cas potentials in fish breeding. In addition, current regulatory and risk assessment frameworks are not fit-for purpose regarding the challenges of CRISPR/Cas notwithstanding that public and regulatory acceptance are key to commercialization of products of the new technology. In this study, we discuss how CRISPR/Cas can be used to overcome some of these limitations focusing on diseases and environmental release in farmed fish aquaculture. We further present technical limitations, regulatory and risk assessment challenges of the use of CRISPR/Cas, and proffer research strategies that will provide much-needed data for regulatory decisions, risk assessments, increased public awareness and sustainable applications of CRISPR/Cas in fish aquaculture with emphasis on Atlantic salmon (Salmo salar) breeding.en_US
dc.identifier.citationOkoli AS, Blix TPB, Myhr AI, Xu W, Xu. Sustainable use of CRISPR/Cas in fish aquaculture: the biosafety perspective. Transgenic research. 2021en_US
dc.identifier.cristinIDFRIDAID 1931153
dc.identifier.doi10.1007/s11248-021-00274-7
dc.identifier.issn0962-8819
dc.identifier.issn1573-9368
dc.identifier.urihttps://hdl.handle.net/10037/23253
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalTransgenic research
dc.relation.projectIDNorges forskningsråd: 295094en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/295094/Norway/Genome editing - a game-changer in aquaculture: Conditions for social and moral acceptance//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.titleSustainable use of CRISPR/Cas in fish aquaculture: the biosafety perspectiveen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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