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dc.contributor.authorLaine, Jessica E
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorGunter, Marc J
dc.contributor.authorFerrari, Pietro
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorTsilidis, Kostas
dc.contributor.authorAune, Dagfinn
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorBergmann, Manuela
dc.contributor.authorBoer, Jolanda M A
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorEricson, Ulrika
dc.contributor.authorStubbendorff, Anna
dc.contributor.authorIbsen, Daniel B
dc.contributor.authorDahm, Christina Catherine
dc.contributor.authorDeschasaux, Mélanie
dc.contributor.authorTouvier, Mathilde
dc.contributor.authorKesse-Guyot, Emmanuelle
dc.contributor.authorSánchez Pérez, Maria-Jose
dc.contributor.authorRodríguez Barranco, Miguel
dc.contributor.authorTong, Tammy Y N
dc.contributor.authorPapier, Keren
dc.contributor.authorKnuppel, Anika
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorMancini, Francesca
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorSrour, Bernard
dc.contributor.authorKühn, Tilman
dc.contributor.authorMasala, Giovanna
dc.contributor.authorAgudo, Antonio
dc.contributor.authorSkeie, Guri
dc.contributor.authorRylander, Charlotta
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorVineis, Paolo
dc.date.accessioned2021-12-27T13:44:03Z
dc.date.available2021-12-27T13:44:03Z
dc.date.issued2021-10-22
dc.description.abstractBackground - Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate the associations of dietary greenhouse gas emissions and land use with all-cause and cause-specific mortality and cancer incidence rates. <p> <p>Methods - Using data from 443 991 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a multicentre prospective cohort, we estimated associations between dietary contributions to greenhouse gas emissions and land use and all-cause and cause-specific mortality and incident cancers using Cox proportional hazards regression models. The main exposures were modelled as quartiles. Co-benefits, encompassing the potential effects of alternative diets on all-cause mortality and cancer and potential reductions in greenhouse gas emissions and land use, were estimated with counterfactual attributable fraction intervention models, simulating potential effects of dietary shifts based on the EAT–Lancet reference diet. <p> <p>Findings - In the pooled analysis, there was an association between levels of dietary greenhouse gas emissions and all-cause mortality (adjusted hazard ratio [HR] 1·13 [95% CI 1·10–1·16]) and between land use and all-cause mortality (1·18 [1·15–1·21]) when comparing the fourth quartile to the first quartile. Similar associations were observed for cause-specific mortality. Associations were also observed between all-cause cancer incidence rates and greenhouse gas emissions, when comparing the fourth quartile to the first quartile (adjusted HR 1·11 [95% CI 1·09–1·14]) and between all-cause cancer incidence rates and land use (1·13 [1·10–1·15]); however, estimates differed by cancer type. Through counterfactual attributable fraction modelling of shifts in levels of adherence to the EAT–Lancet diet, we estimated that up to 19–63% of deaths and up to 10–39% of cancers could be prevented, in a 20-year risk period, by different levels of adherence to the EAT–Lancet reference diet. Additionally, switching from lower adherence to the EAT–Lancet reference diet to higher adherence could potentially reduce food-associated greenhouse gas emissions up to 50% and land use up to 62%. <p> <p>Interpretation Our results indicate that shifts towards universally sustainable diets could lead to co-benefits, such as minimising diet-related greenhouse gas emissions and land use, reducing the environmental footprint, aiding in climate change mitigation, and improving population health. <p> <p>Funding European Commission (DG-SANCO), the International Agency for Research on Cancer (IARC), MRC Early Career Fellowship (MR/M501669/1).en_US
dc.description.sponsorshipEUen_US
dc.identifier.citationLaine, Huybrechts, Gunter, Ferrari, Weiderpass, Tsilidis, Aune, Schulze, Bergmann, Temme, Boer, Agnoli, Ericson, Stubbendorff, Ibsen, Dahm, Deschasaux, Touvier, Kesse-Guyot, Sánchez Pérez, Rodríguez Barranco, Tong, Papier, Knuppel, Boutron-Ruault, Mancini, Severi, Srour, Kühn, Masala, Agudo, Skeie, Rylander, Sandanger, Riboli, Vineis. Co-benefits from sustainable dietary shifts for population and environmental health: an assessment from a large European cohort study. The Lancet Planetary Health. 2021;5(11):e786-e796en_US
dc.identifier.cristinIDFRIDAID 1963452
dc.identifier.doi10.1016/S2542-5196(21)00250-3
dc.identifier.urihttps://hdl.handle.net/10037/23513
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalThe Lancet Planetary Health
dc.relation.projectIDinfo:eu-repo/grantAgreement/Funder/FundingProgram/ProjectNumber/Jurisdiction/ProjectName/ProjectAcronym/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleCo-benefits from sustainable dietary shifts for population and environmental health: an assessment from a large European cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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