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dc.contributor.authorXu, Shanshan
dc.contributor.authorHansen, Solrunn
dc.contributor.authorRautio, Arja
dc.contributor.authorRiitta-Järvelin, Marjo
dc.contributor.authorAbass, Khaled
dc.contributor.authorRysä, Jaana
dc.contributor.authorPalaniswamy, Saranya
dc.contributor.authorHuber, Sandra
dc.contributor.authorGrimalt, Joan O.
dc.contributor.authorDumas, Pierre
dc.contributor.authorOdland, Jon Øyvind
dc.date.accessioned2022-01-03T12:25:59Z
dc.date.available2022-01-03T12:25:59Z
dc.date.issued2021-08-30
dc.description.abstractThe ubiquitous presence of legacy and emerging persistent organic pollutants (POPs) in the environmental matrices poses a potential hazard to the humans and creating public health concerns. The present study aimed to evaluate dioxins, dioxin-like polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and chlorinated paraffins (CPs) concentrations in serum of women (postpartum, pregnant and non-pregnant) from Northern Norway to better understand their exposure and contamination status as well as temporal trends across 2007–2009 (MISA 1) to 2019 (MISA 2). Sixty-two blood samples from the MISA 1 cohort and 38 samples from MISA 2 were randomly selected in this study (n = 100). Ninety samples from postpartum (MISA 1) and pregnant women (MISA 2) were randomly combined into 9 pools, with 9–11 individual samples contributing to each pool keeping the groups of pregnant and postpartum women. Remaining 10 samples from non-pregnant women (MISA 2) were allocated into separate group. Geometric mean, minimum and maximum were used to describe the serum concentrations of pooled POPs in MISA cohort. Mann-Whitney U test and independent sample t-test were applied for trend analysis of blood levels of POPs between MISA 1 and MISA 2. We found the serum concentrations of selected POPs in this study to be at lower range. Serum concentrations of dibenzo-p-dioxins (PCDDs) (p = 0.010), polychlorinated dibenzofurans (PCDFs) (p = 0.002), dioxins-like PCBs (p = 0.001), hexachlorobenzene (HCB) (p < 0.001) and p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) (p = 0.002) were decreased between the studied time. In contrast, the serum concentrations of medium chain chlorinated paraffins showed an increasing trend between 2007 and 2009 and 2019 (p = 0.019). Our findings report a particular concern of emerging contaminant medium chain chlorinated paraffin exposure to humans. Future observational studies with repeated measurements of chlorinated paraffins in general populations worldwide and large sample size are warranted.en_US
dc.identifier.citationXu, Hansen, Rautio, Riitta-Järvelin, Abass, Rysä, Palaniswamy, Huber, Grimalt, Dumas, Odland. Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort study. Environmental Research. 2021en_US
dc.identifier.cristinIDFRIDAID 1936132
dc.identifier.doi10.1016/j.envres.2021.111980
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.urihttps://hdl.handle.net/10037/23572
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironmental Research
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/825762/Norway/Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.titleMonitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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