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dc.contributor.authorBian, Ka
dc.contributor.authorMuppani, Naveen Reddy
dc.contributor.authorElkhadragy, Lobna
dc.contributor.authorWang, Wei
dc.contributor.authorZhang, Cheng
dc.contributor.authorChen, Tenghui
dc.contributor.authorJung, Sungyun
dc.contributor.authorSeternes, Ole Morten
dc.contributor.authorLong, Weiwen
dc.date.accessioned2022-01-12T12:21:31Z
dc.date.available2022-01-12T12:21:31Z
dc.date.issued2015-12-19
dc.description.abstractPosttranslational modifications (PTMs), such as phosphorylation and ubiquitination, play critical regulatory roles in the assembly of DNA damage response proteins on the DNA damage site and their activities in DNA damage repair. Tyrosyl DNA phosphodiesterase 2 (TDP2) repairs Topoisomerase 2 (Top2)-linked DNA damage, thereby protecting cancer cells against Top2 inhibitors-induced growth inhibition and cell death. The regulation of TDP2 activity by post-translational modifications in DNA repair, however, remains unclear. In the current study, we have found that ERK3, an atypical MAPK, phosphorylates TDP2 at S60 and regulates TDP2’s phosphodiesterase activity, thereby cooperatively protecting lung cancer cells against Top2 inhibitors-induced DNA damage and growth inhibition. As such, our study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells’ DNA damage response and chemoresistance to Top2 inhibitors.en_US
dc.identifier.citationBian, Muppani, Elkhadragy, Wang W, Zhang, Chen, Jung, Seternes om, Long. ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells. OncoTarget. 2015;7(6):6665-6675en_US
dc.identifier.cristinIDFRIDAID 1346075
dc.identifier.doi10.18632/oncotarget.6682
dc.identifier.issn1949-2553
dc.identifier.urihttps://hdl.handle.net/10037/23668
dc.language.isoengen_US
dc.publisherImpact journalsen_US
dc.relation.journalOncoTarget
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 The Author(s)en_US
dc.titleERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cellsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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