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Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina

Permanent lenke
https://hdl.handle.net/10037/23774
DOI
https://doi.org/10.3390/molecules26247560
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Åpne
article.pdf (713.0Kb)
Publisert versjon (PDF)
Dato
2021-12-13
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Jenssen, Marte; Kristoffersen, Venke; Motiram-Corral, Kumar; Isaksson, Johan; Rämä, Teppo; Andersen, Jeanette Hammer; Hansen, Espen; Østnes Hansen, Kine
Sammendrag
As part of our search for bioactive metabolites from understudied marine microorganisms, the new chlorinated metabolite chlovalicin B (1) was isolated from liquid cultures of the marine basidiomycete Digitatispora marina, which was collected and isolated from driftwood found at Vannøya, Norway. The structure of the novel compound was elucidated by spectroscopic methods including 1D and 2D NMR and analysis of HRMS data, revealing that 1 shares its molecular scaffold with a previously isolated compound, chlovalicin. This represents the first compound isolated from the Digitatispora genus, and the first reported fumagillin/ovalicin-like compound isolated from Basidiomycota. Compound 1 was evaluated for antibacterial activities against a panel of five bacteria, its ability to inhibit bacterial biofilm formation, for antifungal activity against Candida albicans, and for cytotoxic activities against malignant and non-malignant human cell lines. Compound 1 displayed weak cytotoxic activity against the human melanoma cell line A2058 (~50% survival at 50 µM). No activity was detected against biofilm formation or C. albicans at 50 µM, or against bacterial growth at 100 µM nor against the production of cytokines by the human acute monocytic leukemia cell line THP-1 at 50 µM
Er en del av
Jenssen, M. (2022). Bioprospecting of marine microorganisms for the discovery of antibacterial compounds - Isolation, structure elucidation and bioactivity assessment of marine microbial natural products. (Doctoral thesis). https://hdl.handle.net/10037/24722.
Forlag
MDPI
Sitering
Jenssen, Kristoffersen, Motiram-Corral, Isaksson, Rämä, Andersen, Hansen, Østnes Hansen. Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina. Molecules. 2021;26(24)
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  • Artikler, rapporter og annet (Norges fiskerihøgskole) [1053]
Copyright 2021 The Author(s)

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