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dc.contributor.authorvan der Wal, Yorick Andreas
dc.contributor.authorJenberie, Shiferaw
dc.contributor.authorNordli, Henriette
dc.contributor.authorGreiner-Tollersrud, Linn
dc.contributor.authorKool, Jaap
dc.contributor.authorJensen, Ingvill
dc.contributor.authorJørgensen, Jorunn
dc.date.accessioned2022-01-25T13:56:31Z
dc.date.available2022-01-25T13:56:31Z
dc.date.issued2021-06-01
dc.description.abstractThe intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response versus responses in the lymphatic organs: spleen and head kidney. We observed a major increase of leukocytes, total IgM antibody secreting cells (ASC), and P. salmonis-specific ASC in the PerC at 3- and 6-weeks post infection (wpi). The increase in ASC frequency was more prominent in the spleen and PerC compared to the head kidney during the observed 6 wpi. The serum antibody response included P. salmonis-specific antibodies and non-specific antibodies recognizing the non-related bacterial pathogen Yersinia ruckeri and the model antigen TNP-KLH. Finally, we present evidence that supports a putative role for the adipose tissue in the PerC immune response.en_US
dc.identifier.citationvan der Wal, Jenberie, Nordli, Greiner-Tollersrud, Kool, Jensen, Jørgensen. The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection. Developmental and Comparative Immunology. 2021;123en_US
dc.identifier.cristinIDFRIDAID 1970494
dc.identifier.doi10.1016/j.dci.2021.104125
dc.identifier.issn0145-305X
dc.identifier.issn1879-0089
dc.identifier.urihttps://hdl.handle.net/10037/23810
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalDevelopmental and Comparative Immunology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleThe importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infectionen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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