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dc.contributor.authorHarikrishnan, Ramasamy
dc.contributor.authorDevi, Gunapathy
dc.contributor.authorBalasundaram, Chellam
dc.contributor.authorVan Doan, Hien
dc.contributor.authorJaturasitha, Sanchai
dc.contributor.authorRingø, Einar
dc.contributor.authorFaggio, Caterina
dc.date.accessioned2022-02-14T14:43:23Z
dc.date.available2022-02-14T14:43:23Z
dc.date.issued2021-01-12
dc.description.abstractThe effect of chrysophanic acid (CA) (2, 4, and 8 mg kg<sup>−1</sup>) on the immunity and immune-related gene profile of Catla catla against Aeromonas hydrophila is reported. In both control and treated groups fed with 2 mg kg<sup>−1</sup> (2 CA), the phagocytosis, hemolytic, myeloperoxidase content, and superoxide anion production decreased significantly between 6th and 8th weeks, whereas when fed with 4 mg kg<sup>−1</sup> CA (4 CA) the H2O2 production and nitric oxide synthase increased significantly between 4th and 8th week. When fed with 2 CA and 4 CA diets, the total protein, bactericidal, and antibody titer increased significantly from the 4th week onwards. When fed with 2 CA, the IL-1β and IL-10 mRNA expression of head kidney leucocytes were significant between weeks 6 and 8. The expressions of toll-like receptors significantly increased when fed with a 4 CA diet from 4th week onwards. The 4 CA group significantly increased in TNF-α, TNF receptor-associated factor 6 (NOD), which influences protein expression, after the 4th week. The mRNA transcription of MHCI, lysozyme-chicken and goose type expressions significantly increased in 4 CA group within the 4th week. In summary, the dietary administration of 4 mg kg<sup>−1</sup> of CA (4 CA) provides better immunity and enhances the up-regulation of immune-related genes in Catla against A. hydrophila.en_US
dc.identifier.citationHarikrishnan, Devi, Balasundaram, Van Doan H, Jaturasitha S, Ringø E, Faggio C. Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila. Scientific Reports. 2021;11en_US
dc.identifier.cristinIDFRIDAID 1977805
dc.identifier.doi10.1038/s41598-020-79629-9
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/24048
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleEffect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophilaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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