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A single-cell type transcriptomics map of human tissues

Permanent lenke
https://hdl.handle.net/10037/24317
DOI
https://doi.org/10.1126/sciadv.abh2169
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Åpne
article.pdf (5.875Mb)
Publisert versjon (PDF)
Dato
2021-07-28
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Karlsson, Max; Cheng, Zhang; Mear, Lorén; Zhong, Wen; Digre, Andreas; Katona, Barbola; Sjöstedt, Evelina; Butler, Lynn; Odeberg, Jacob; Dusart, Philip James; Edfors, Fredrik; Oksvold, Per; von Feilitzen, Kalle; Zwahlen, Martin; Arif, Muhammad; Altay, Ozlem; Li, Xiangyu; Ozcan, Mehmet; Mardinoglu, Adil; Fagerberg, Linn; Mulder, Jan; Luo, Younglun; Ponten, Fredrik; Uhlén, Mathias; Lindskog, Cecilia
Sammendrag
Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in the human body. Here, we combined single-cell transcriptomics analysis with spatial antibodybased protein profiling to create a high-resolution single–cell type map of human tissues. An open access atlas has been launched to allow researchers to explore the expression of human protein-coding genes in 192 individual cell type clusters. An expression specificity classification was performed to determine the number of genes elevated in each cell type, allowing comparisons with bulk transcriptomics data. The analysis highlights distinct expression clusters corresponding to cell types sharing similar functions, both within the same organs and between organs.
Forlag
American Association for the Advancement of Science
Sitering
Karlsson, Cheng, Mear, Zhong, Digre A, Katona, Sjöstedt E, Butler LB, Odeberg JO, Dusart PJ, Edfors F, Oksvold, von Feilitzen, Zwahlen, Arif M, Altay, Li X, Ozcan, Mardinoglu A, Fagerberg, Mulder J, Luo, Ponten F, Uhlén M, Lindskog C. A single-cell type transcriptomics map of human tissues. Science Advances. 2021
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Samlinger
  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2021 The Author(s)

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