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No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial

Permanent lenke
https://hdl.handle.net/10037/24333
DOI
https://doi.org/10.1016/j.sleepx.2021.100040
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article.pdf (495.2Kb)
Publisert versjon (PDF)
Dato
2021-10-19
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Larsen, Anette Uhlving; Hopstock, Laila Arnesdatter; Jorde, Rolf; Grimnes, Guri
Sammendrag

Background Vitamin D has been linked to sleep health in observational studies. Data from randomized controlled trials (RCTs) with vitamin D is scarce.

Methods This study presents the results of a secondary analysis of 189 vitamin D insufficient participants (47.1% women) in a previously performed RCT, of which 92 were randomized to vitamin D (100,000 IU (2500 μg) as a bolus dose followed by 20,000 IU (500 μg) per week), and 97 to placebo. At baseline and after 4 months at the end of the study serum 25-hydroxyvitamin D (s-25(OH)D) was measured, and the study questionnaire assessing sleep duration, daytime sleepiness, and symptoms of insomnia, was completed.

Results At baseline, mean s-25(OH)D was 35.0 ± 11.8 and 35.5 ± 13.3 nmol/L in the vitamin D and placebo groups, respectively. After four months, we found no statistically significant differences between the intervention groups in any of the assessed sleep outcomes, neither when stratified by sex, nor when performed in subgroups based on baseline or end of study s-25(OH)D level or presence of sleep complaints at baseline.

Conclusions We were not able to demonstrate a significant effect of vitamin D supplementation on sleep in this vitamin D insufficient population.

Er en del av
Larsen, A.U. (2022). Vitamin D: Relations with Sleep and Bone Mineral Density. Insights from the Tromsø Study and randomized controlled trials. (Doctoral thesis). https://hdl.handle.net/10037/25239
Forlag
Elsevier
Sitering
Larsen AU, Hopstock, Jorde, Grimnes. No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Sleep Medicine: X. 2021;3:1-8
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2021 The Author(s)

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