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Validation of a graded prognostic model in patients with brain metastases treated with whole-brain radiotherapy instead of radiosurgery

Permanent lenke
https://hdl.handle.net/10037/24423
DOI
https://doi.org/10.21873/invivo.12412
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article.pdf (266.8Kb)
Publisert versjon (PDF)
Dato
2021-05
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba
Sammendrag
Background/Aim: The aim of this study was to analyze the survival predictions obtained from a recent graded prognostic model developed and validated in Japan.

Patients and Methods: This was a retrospective single-institution analysis of 249 patients, managed with whole-brain radiotherapy for brain metastases. The sum of scores was calculated as in the Japanese study. The following parameters were included: number of brain metastases, volume of the largest lesion, sex, Karnofsky performance status, primary cancer type, control of primary cancer, and presence of extra-cerebral metastases.

Results: Median overall survival was 3.0 months (95% CI= 2.6-3.4 months). The median sum of scores was 12, range=0-29. Statistically significant differences were observed between all prognostic strata.

Conclusion: The graded prognostic model is also applicable to patients treated with whole-brain rather than stereotactic radiotherapy.

Forlag
International Institute of Anticancer Research
Sitering
Nieder, Mannsåker, Yobuta. Validation of a graded prognostic model in patients with brain metastases treated with whole-brain radiotherapy instead of radiosurgery. In Vivo. 2021;35(3):1569-1572
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2021 The Author(s)

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