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dc.contributor.authorKazimierczak, Katarzyna
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorErsland, Lars
dc.contributor.authorSpecht, Karsten
dc.contributor.authorDumitru, Magda L.
dc.contributor.authorSandøy, Lydia B.
dc.contributor.authorHugdahl, Kenneth
dc.date.accessioned2022-03-29T08:48:31Z
dc.date.available2022-03-29T08:48:31Z
dc.date.issued2022-01-18
dc.description.abstractDichotic listening along with the right-ear advantage (REA) has been a standard method of investigating auditory laterality ever since it was first introduced into neuropsychology in the early 1960s. Beginning in the 1980s, authors reported that it was possible to modulate the bottom-up driven perceptual REA by instructing subjects to selectively attend to and report only from the right or left ear. In the present study, we investigated neuronal correlates of both the bottom-up and top-down modulation of the REA through two fMRI analysis approaches: a traditional region approach and a network connectivity approach. Blood-Oxygenation-Level-Dependent (BOLD) fMRI data were acquired while subjects performed the standard forced-attention paradigm. We asked two questions, could the behavioral REA be replicated in unique brain markers, and second if the profound instruction-induced modulation of the REA found in behavioral data would correspond to a similar modulation of brain activation, both region- and network-specific modulations. The subjects were 70 healthy adult right-handers, about half men and half women. fMRI data were acquired in a 3T MR scanner, and the behavioral results replicated previous findings with a REA in the non-forced (NF) and forced-right (FR) conditions, and a tendency for a left-ear advantage (LEA) in the FLcondition. The fMRI data showed unique activations in the speech perception areas of the left temporal lobe when directly contrasted with activations in the homologous right side. However, there were no remaining unique activations when the FR- and FL-conditions were contrasted against each other, and with the NF-condition, using a conservative significance thresholding. The fMRI results are conceptualized within a network connectivity frame of reference, especially with reference to the extrinsic mode network (EMN). The EMN is a generalized task-positive network that is upregulated whenever the task demands exceed a certain threshold irrespective of the specifics and demands of the task. This could explain the similarity of activations for the FR- and FL-conditions, despite the clear differences in behavior.en_US
dc.identifier.citationKazimierczak, Craven, Ersland, Specht, Dumitru ML, Sandøy LB, Hugdahl. Combined fMRI region- and network-analysis reveal new insights of top-down modulation of bottom-up processes in auditory laterality. Frontiers in Behavioral Neuroscience. 2022;15en_US
dc.identifier.cristinIDFRIDAID 1989782
dc.identifier.doi10.3389/fnbeh.2021.802319
dc.identifier.issn1662-5153
dc.identifier.urihttps://hdl.handle.net/10037/24615
dc.language.isoengen_US
dc.relation.journalFrontiers in Behavioral Neuroscience
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/693124/EU/Perception of voices that do not exist: Tracking the temporal signatures of auditory hallucinations/ONOFF/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleCombined fMRI region- and network-analysis reveal new insights of top-down modulation of bottom-up processes in auditory lateralityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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