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dc.contributor.authorKalidasan, Viveka
dc.contributor.authorYang, Xin
dc.contributor.authorXiong, Ze
dc.contributor.authorLi, Renee R.
dc.contributor.authorYao, Haicheng
dc.contributor.authorGodaba, Hareesh
dc.contributor.authorObuobi, Sybil Akua Okyerewa
dc.contributor.authorSingh, Priti
dc.contributor.authorGuan, Xin
dc.contributor.authorTian, Xi
dc.contributor.authorKurt, Selman A.
dc.contributor.authorLi, Zhipeng
dc.contributor.authorMukherjee, Devika
dc.contributor.authorRajarethinam, Ravisankar
dc.contributor.authorChong, Choon Seng
dc.contributor.authorWang, Jiong-Wei
dc.contributor.authorEe, Pui Lai Rachel
dc.contributor.authorLoke, Weiqiang
dc.contributor.authorTee, Benjamin C. K.
dc.contributor.authorOuyang, Jianyong
dc.contributor.authorCharles, Christopher J.
dc.contributor.authorHo, John S.
dc.date.accessioned2022-03-30T13:06:11Z
dc.date.available2022-03-30T13:06:11Z
dc.date.issued2021-10-15
dc.description.abstractMonitoring surgical wounds post-operatively is necessary to prevent infection, dehiscence and other complications. However, the monitoring of deep surgical sites is typically limited to indirect observations or to costly radiological investigations that often fail to detect complications before they become severe. Bioelectronic sensors could provide accurate and continuous monitoring from within the body, but the form factors of existing devices are not amenable to integration with sensitive wound tissues and to wireless data transmission. Here we show that multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites. We show in live pigs that the sutures can monitor wound integrity, gastric leakage and tissue micromotions, and in rodents that the healing outcomes are equivalent to those of medical-grade sutures. Battery-free wirelessly operated bioelectronic sutures may facilitate post-surgical monitoring in a wide range of interventions.en_US
dc.identifier.citationKalidasan, Yang X, Xiong, Li, Yao, Godaba, Obuobi SAO, Singh, Guan X, Tian, Kurt, Li Z, Mukherjee, Rajarethinam, Chong, Wang J, Ee PLR, Loke, Tee, Ouyang, Charles, Ho. Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds . Nature Biomedical Engineering. 2021;5:1217-1227en_US
dc.identifier.cristinIDFRIDAID 1947390
dc.identifier.doi10.1038/s41551-021-00802-0
dc.identifier.issn2157-846X
dc.identifier.urihttps://hdl.handle.net/10037/24658
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalNature Biomedical Engineering
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleWirelessly operated bioelectronic sutures for the monitoring of deep surgical woundsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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