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dc.contributor.authorDanielsen, Kjersti
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorOlsen, Anne Olaug
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorOlsen, Karina
dc.contributor.authorCassano, P. A.
dc.contributor.authorFurberg, Anne-Sofie
dc.date.accessioned2022-05-02T12:43:54Z
dc.date.available2022-05-02T12:43:54Z
dc.date.issued2014-07-24
dc.description.abstractBackground Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population. Objectives To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex.<p> <p>Methods A cross-sectional study including 10 521 participants aged 30–79 years from the Tromsø Study cohort was performed; 1137 participants reported lifetime psoriasis of a mainly mild character. The new harmonized definition of metabolic syndrome was used in the multivariable logistic regression analysis.<p> <p>Results There was a uniformly higher prevalence of metabolic syndrome in men and women with psoriasis compared with those without across all age groups. In women, psoriasis was associated with a 3 8-times higher odds of metabolic syndrome at age 30 years (95% confidence interval 1 5–9 7), with a decreasing odds ratio with increasing age. In men, psoriasis was associated with a stable 1 35-times higher odds of metabolic syndrome (95% confidence interval 1 1– 1 6) at all ages. Abdominal obesity was the most frequent metabolic syndrome component in women in this study, and there was indication of a dose–response relationship between psoriasis severity, indicated through treatment, and having a high waistline in women.<p> <p>Conclusions This study suggests age and sex variations in the risk of metabolic syndrome among individuals with psoriasis. Given the high prevalence of psoriasis and the significantly elevated burden of metabolic syndrome in this patient group, there may be a benefit from targeted screening of metabolic syndrome among individuals with psoriasis regardless of age and disease severity.en_US
dc.identifier.citationDanielsen K, Wilsgaard T, Olsen AO, Eggen AE, Olsen K, Cassano, Furberg AS. Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences. British Journal of Dermatology. 2015;172(2):419-427en_US
dc.identifier.cristinIDFRIDAID 1251941
dc.identifier.doi10.1111/bjd.13288
dc.identifier.issn0007-0963
dc.identifier.issn1365-2133
dc.identifier.urihttps://hdl.handle.net/10037/24971
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalBritish Journal of Dermatology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)en_US
dc.titleElevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differencesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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