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dc.contributor.authorMikkilä, Saija
dc.contributor.authorJohansson, Jonas
dc.contributor.authorNordström, Anna Hava
dc.contributor.authorNordström, Peter
dc.contributor.authorEmaus, Nina
dc.contributor.authorHandegård, Bjørn Helge
dc.contributor.authorMorseth, Bente
dc.contributor.authorWelde, Boye
dc.date.accessioned2022-05-12T09:17:31Z
dc.date.available2022-05-12T09:17:31Z
dc.date.issued2022-01-26
dc.description.abstractAims<p> <p>The aim was to investigate the long-term association between leisure time physical activity and hip areal bone mineral density (aBMD), in addition to change in hip aBMD over time, in 32–86 years old women and men.<p> <p>Methods <p>Data were retrieved from the 2001, 2007–2008, and 2015–2016 surveys of the Tromsø Study, a longitudinal population study in Norway. Leisure time physical activity was assessed by the four-level Saltin-Grimby Physical Activity Level Scale which refers to physical exertion in the past twelve months. Hip aBMD was assessed by Dual-Energy X-ray Absorptiometry. Linear Mixed Model analysis was used to examine long-term associations between physical activity and hip aBMD (n = 6324). In addition, the annual change in hip aBMD was analyzed in a subsample of 3199 participants.<p> <p>Results <p>Physical activity was significantly and positively associated with total hip aBMD in the overall cohort (p<0.005). Participants who reported vigorous activity had 28.20 mg/cm<sup>2</sup> higher aBMD than those who were inactive (95% CI 14.71; 41.69, controlled for confounders), and even light physical activity was associated with higher aBMD than inactivity (8.32 mg/cm<sup>2</sup> , 95% CI 4.89; 11.76). Associations between physical activity and femoral neck aBMD yielded similar results. Hip aBMD decreased with age in both sexes, although more prominently in women. From 2001 to 2007–2008, aBMD changed by –5.76 mg/cm<sup>2</sup> per year (95% CI – 6.08; –5.44) in women, and –2.31 mg/cm2 (95% CI –2.69; –1.93), in men. From 2007–2008 to 2015–2016, the change was –4.45 mg/cm<sup>2</sup> per year (95% CI –4.84; –4.06) in women, and –1.45 mg/cm<sup>2</sup> (95% CI –1.92; –0.98) in men.<p> <p>Conclusions In this cohort of adult men and women, physical activity levels were positively associated with hip aBMD in a dose-response relationship. Hip aBMD decreased with age, although more pronounced in women than men.en_US
dc.identifier.citationMikkilä SP, Johansson J, Nordström AH, Nordström P, Emaus N, Handegård BHH, Morseth B, Welde B. A 15-year follow-up study of hip bone mineral density and associations with leisure time physical activity. The Tromsø Study 2001-2016. PLOS ONE. 2022;17(1)en_US
dc.identifier.cristinIDFRIDAID 1996567
dc.identifier.doi10.1371/journal.pone.0262228
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/25098
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLOS ONE
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleA 15-year follow-up study of hip bone mineral density and associations with leisure time physical activity. The Tromsø Study 2001-2016en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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